Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine
Information source: University of Lausanne Hospitals
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postoperative Pain
Intervention: Lidocaine, (Drug); Ketamine (Drug); association ketamine-lidocaine (Drug); Placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: University of Lausanne Hospitals Official(s) and/or principal investigator(s): Christian Kern, Study Director, Affiliation: University of Lausanne Hospitals
Summary
The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine
and ketamine in the perioperative period of abdominal surgery.
Clinical Details
Official title: Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Cumulative morphine consumption
Secondary outcome: Pain scoresMechanical hyperalgesia Occurrence of side effects
Detailed description:
Optimal postoperative pain management facilitates rehabilitation immediately after abdominal
surgery. Multiple studies have demonstrated that successful postoperative analgesia also
reduces perioperative complications and improves patient comfort, thereby providing many
benefits for the patient. In acute postoperative pain management intravenous lidocaine
and/or ketamine have been advocated because of their morphine-sparing effect.
Eligibility
Minimum age: 20 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- abdominal surgery by laparotomy
Exclusion Criteria:
- laparoscopy
- history of chronic pain
- opioid self-administration
- psychiatric disorders
- difficulties with communication
- renal or hepatic dysfunction
- ASA physical status > 3
Locations and Contacts
University Hospital Center and University, Lausanne, Vaud CH-1011, Switzerland
Additional Information
Starting date: December 2005
Last updated: September 21, 2011
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