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Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels

Information source: USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Nutritional Requirements

Intervention: placebo (Dietary Supplement); selenium as L-selenomethionine (Dietary Supplement)

Phase: N/A

Status: Completed

Sponsored by: USDA Grand Forks Human Nutrition Research Center

Official(s) and/or principal investigator(s):
Gerald F Combs, PhD, Principal Investigator, Affiliation: USDA Grand Forks Human Nutrition Research Center


In this study, we will evaluate the effectiveness of several doses of oral selenomethionine in raising biomarkers of selenium status including plasma selenium concentrations.

Clinical Details

Official title: Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels

Study design: Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Evaluation of effectiveness of consuming oral doses of L-selenomethionine in raising plasma selenium concentrations

Secondary outcome: Biomarkers of selenium status will be determined in urine, buccal cells, and plasma. White blood cells will be analyzed to identify DNA damage, reflecting the degree of oxidative damage and evaluate the status of antioxidant repair mechanisms.

Detailed description: Results of studies with animal tumor models and human clinical trials suggest that the essential nutrient selenium can be anti-tumorigenic if consumed at levels greater than nutritional requirements. If it is possible to increase plasma selenium concentrations above 120 nanograms per milliliter with less than 200 micrograms of selenium daily, then it is possible that supplementation can be accomplished through the use of selenium-containing foods.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- able to swallow capsules

- body mass index less than 40

Exclusion Criteria:

- Pregnancy

- Chronic liver or kidney disease

- taking medication that might affect liver and/or kidney

- blood pressure 140/90 or higher

- already taking more than 50 micrograms of selenium

Locations and Contacts

USDA Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202, United States
Additional Information

Related publications:

Jackson MI, Combs GF Jr. Selenium and anticarcinogenesis: underlying mechanisms. Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):718-26. doi: 10.1097/MCO.0b013e3283139674. Review.

Starting date: November 2005
Last updated: December 4, 2008

Page last updated: August 23, 2015

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