Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension
Information source: Anhui Medical University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Lower Urinary Tract Symptoms
Intervention: amlodipine (Drug); terazosin (Drug); amlodipine plus terazosin (Drug)
Phase: N/A
Status: Completed
Sponsored by: Anhui Medical University Official(s) and/or principal investigator(s):
Ping Liu, PhD, Study Director, Affiliation: Biomedical Institute of Anhui Medical University
Summary
The aim of this study was to investigate the efficacy and safety of low dose amlodipine
alone, or combined with low dose terazosin in male patients with both lower urinary tract
symptoms and hypertension.
Clinical Details
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Active Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: The primary efficacy outcomes were changes in LUTS.
Secondary outcome: Changes in blood pressure were used as secondary outcomes of efficacy.
Eligibility
Minimum age: 50 Years.
Maximum age: 75 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
1. Men 50-75 years old
2. with LUTS [International Prostate Symptom Score (IPSS) >= 10].
3. Stage 1 or 2 essential hypertension (SBP >= 140 mm Hg and < 180 mm Hg and/or DBP >= 90
mm Hg and < 110 mm Hg)
Exclusion Criteria:
1. A history of postural hypotension
2. Secondary hypertension
3. Prostate cancer
4. Prostate surgery or other intervention
5. Use of any agents to influence the LUTS symptoms in the last 4 weeks
6. Other severe diseases
Locations and Contacts
Biomedicine Inistitute of Anhui Medical University, Hefei, Anhui 230032, China
Additional Information
Starting date: July 2006
Ending date: October 2006
Last updated: June 5, 2008
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