The Effect of Imipramine on Early Information Processing

Condition(s) targeted: Healthy Volunters

Intervention: imipramine (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Bispebjerg Hospital

Official(s) and/or principal investigator(s):
Birte Glenthoj, MD, DMSc., Study Director, Affiliation: Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychaitric Center Glostrup, Ndr. Ringvej, DK-2600 Glostrup, Denmark

We wanted to compare the relation of two different psychophysiological paradigms (PrePulse Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we wanted to test the effect of the combined serotonin- and noradrenaline re-uptake inhibitor, imipramine, on these measures. The primary hypothesis was that PPI and P50 gating would not correlate with each other at baseline. The secondary hypothesis was that increased noradrenergic and serotonergic activity would disrupt PPI as well as P50 gating.

Official title: Early Information Processing in Healthy Controls: Studies on the Relation Between Two Different Paradigms (PPI and P50ERP) and Effects of Pharmacological Interventions

Study design: Diagnostic, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacodynamics Study

Primary outcome:

PrePulse Inhibition of the startle response

P50 ERP gating

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Male subjects

- Good Physical and Mental Health meeting criteria "never mentally ill", which will be

evaluated with a medical history checklist, ECG

- Non smokers

Exclusion Criteria:

- Current use of any medication

- Any subject who has received any investigational medication within 30 days prior to

the start of this study

- History of neurologic illness

- History of psychiatric illness in first-degree relatives, evaluated with DSM-IV

criteria

- History of alcohol and drug abuse. Positive urine screening for amphetamine, cocaine,

cannabis, or esctacy.

Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Center Glostrup, Glostrup DK-2600, Denmark

Center for Neuropsychiatric Schizophrenia Research (CNSR)

Starting date: September 2004
Last updated: September 11, 2006