Relationship Between Topiramate Use and Ocular Angle Status
Information source: Chinese University of Hong Kong
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Glaucoma, Angle-Closure
Intervention: Topiramate (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: Chinese University of Hong Kong Official(s) and/or principal investigator(s):
Dexter YL Leung, MRCS, Principal Investigator, Affiliation: Hong Kong Eye Hospital
Howan Leung, MRCP, Principal Investigator, Affiliation: Chinese University of Hong Kong
Summary
We test the hypothesis whether topiramate narrows the angles which may render Asians more
likely to suffer from acute angle closure glaucoma.
Clinical Details
Official title: Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study
Study design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety Study
Primary outcome: Change(s) in ophthalmic parameters measured at baseline and after 4 weeks of treatment, including:best-corrected visual acuity, refraction, Goldmann applanation tonometry, Gonioscopy, dilated fundus examination, and ultrasound biomicroscopy of angle and anterior segment.
Detailed description:
Topiramate is approved for the treatment of epilepsy and prophylaxis of migraine attacks.
There were case reports of acute angle closure glaucoma (AACG) associated with its use. AACG
is particularly common in Asians because of a higher prevalence of narrow angle., we test the
hypothesis whether topiramate narrows the angles which may render them more likely to suffer
from AACG.
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Participants aged 18-75 with an indication for starting topiramate.
Exclusion Criteria:
- Patients with known allergy or intolerance to topiramate.
- Recent exposure to topiramate (<3 months).
- Moderate to severe renal failure.
- Known history of renal calculi or hepatic failure
- Inability to give informed consent.
- Pregnant women or women of child-bearing age who do not practise an acceptable means
of contraception.
- Patients known to have angle-closure glaucoma.
Locations and Contacts
Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Eye Hospital, Kowloon, Hong Kong
Additional Information
Starting date: September 2004
Ending date: July 2007
Last updated: October 30, 2007
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