Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery
Information source: Federal University of the Valleys of Jequitinhonha and Mucuri
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pain,; Edema,; Trismus
Intervention: Dexamethasone (Drug); Methylprednisolone (Drug)
Phase: N/A
Status: Completed
Sponsored by: Federal University of the Valleys of Jequitinhonha and Mucuri Official(s) and/or principal investigator(s): Carlos Eduardo Alcântara, MsC, Principal Investigator, Affiliation: Federal University of the Valleys of Jequitinhonha and Mucuri
Summary
The main aim of the present study was to investigate the effect of preemptive dexamethasone
and methylprednisolone to prevent pain, swelling and limitation in mouth opening following
third molar extraction.
Clinical Details
Official title: Preemptive Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery: a Split-mouth Randomized Triple-blind Clinical Trial
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Postoperative sequelae following thir molar extraction
Secondary outcome: Analgesic consumption; duration of surgery
Detailed description:
Third molar surgery is often associated with significant post-surgical sequelae. The trauma
caused to soft and bony tissue can result in considerable pain, swelling and trismus.
Symptoms begin gradually having a peak 2 days after extraction. The use of corticosteroids
such as dexamethasone and methylprednisolone can be a valuable tool when performing moderate
to moderately severe oral surgical procedures. No clear consensus have emerged yet regarding
patient selection, dosage, timing and type of administration of steroid. In this light, this
clinical trial aim to compare the effect of preemptive dexamethasone and methylprednisolone
to prevent pain, swelling and limitation in mouth opening following third molar extraction.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with indication of asymptomatic bilateral extractions of lower third molars
- Aged 18 years or older;
- Have a good health and no disease;
Exclusion Criteria:
- Patients with history of any medication treatment within 15 days before the beginning
of the research, history of allergy to the drugs, substances or materials used in
this study, pregnancy or lactation
Locations and Contacts
Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100000, Brazil
Additional Information
Starting date: April 2011
Last updated: May 21, 2012
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