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Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery

Information source: Federal University of the Valleys of Jequitinhonha and Mucuri
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain,; Edema,; Trismus

Intervention: Dexamethasone (Drug); Methylprednisolone (Drug)

Phase: N/A

Status: Completed

Sponsored by: Federal University of the Valleys of Jequitinhonha and Mucuri

Official(s) and/or principal investigator(s):
Carlos Eduardo Alcântara, MsC, Principal Investigator, Affiliation: Federal University of the Valleys of Jequitinhonha and Mucuri

Summary

The main aim of the present study was to investigate the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

Clinical Details

Official title: Preemptive Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery: a Split-mouth Randomized Triple-blind Clinical Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Postoperative sequelae following thir molar extraction

Secondary outcome: Analgesic consumption; duration of surgery

Detailed description: Third molar surgery is often associated with significant post-surgical sequelae. The trauma caused to soft and bony tissue can result in considerable pain, swelling and trismus. Symptoms begin gradually having a peak 2 days after extraction. The use of corticosteroids such as dexamethasone and methylprednisolone can be a valuable tool when performing moderate to moderately severe oral surgical procedures. No clear consensus have emerged yet regarding patient selection, dosage, timing and type of administration of steroid. In this light, this clinical trial aim to compare the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with indication of asymptomatic bilateral extractions of lower third molars

- Aged 18 years or older;

- Have a good health and no disease;

Exclusion Criteria:

- Patients with history of any medication treatment within 15 days before the beginning

of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation

Locations and Contacts

Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais 39100000, Brazil
Additional Information

Starting date: April 2011
Last updated: May 21, 2012

Page last updated: August 23, 2015

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