Evaluation of Optical Coherence Tomography Combined With Fundus Color Photos for Diagnosis of Choroidal Neovessels in Age-related Macular Degeneration
Information source: Assistance Publique - Hôpitaux de Paris
Information obtained from ClinicalTrials.gov on October 04, 2010
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Age-Related Macular Degeneration; Choroidal Neo-vessels
Intervention: tests (Other)
Phase: N/A
Status: Not yet recruiting
Sponsored by: Assistance Publique - Hôpitaux de Paris Official(s) and/or principal investigator(s):
Ramin TADAYONI, MD,PhD, Principal Investigator, Affiliation: Assistance Publique - Hôpitaux de Paris
Overall contact:
Ramin TADAYONI, MD,PhD, Phone: 00 33 1 49 95 64 88, Email: ramin.tadayoni@lrb.aphp.fr
Summary
Determination of the sensitivity and specificity of different combinations of imaging
techniques (spectral domain optical coherence tomography, fundus photography and fluorescein
angiography) used for the diagnosis of choroidal neovessels complicating age - related
macular degeneration. This information will help to determine the choice of the most
suitable combination for the above diagnosis.
Clinical Details
Official title: Evaluation of the Sensitivity and Specificity of Optical Coherence Tomography Combined With Fundus Color Photos for Diagnosis of Choroidal Neovessels in Age-related Macular Degeneration
Study design: Observational Model: Cohort, Time Perspective: Cross-Sectional
Primary outcome: Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photos in the diagnosis of choroidal neovessels in age- related macular degeneration.
Secondary outcome: Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography in the diagnosis of choroidal neovessels in age - related macular degeneration.Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography, and of fluorescein angiography combined with fundus color photography. Rate of unusable images for each technique Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels. Evaluation of the intra-and inter-reader reproducibility of the diagnosis of choroidal neovessels in age-related macular degeneration using fluorescein angiography combined with fundus color photography.
Detailed description:
The following combinations will be studied: spectral domain optical coherence tomography
(OCT) + fundus photography; fluorescein angiography + fundus photography and the combination
of all three techniques (OCT+ fundus photography + fluorescein angiography).The sensitivity
and specificity of the latter combination will be assessed by comparison with the results
for this combination reported by several readers. Inter- and intra-observer reproducibility
of the different combinations will also be studied.
Eligibility
Minimum age: 50 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age> 50 years
- First visit for suspicion of choroidal neo-vessels complicating age related macular
degeneration
- Fundus color photographs , FLUORESCEIN angiography and OCT prescription
Exclusion Criteria:
- Age < 50 years
- Diabetes
- Central vein occlusion Macular hole Epi-retinal membrane Retinal detachment Macular
hemorrhage more than the 1/3 of the lesion
- History of macular laser, PDT or intra-vitreal injection
Locations and Contacts
Ramin TADAYONI, MD,PhD, Phone: 00 33 1 49 95 64 88, Email: ramin.tadayoni@lrb.aphp.fr
Hôpital LARIBOISIERE Service d'Ophtalmologie, Paris 75010, France
Additional Information
Starting date: June 2010
Last updated: April 30, 2010
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