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Evaluation of Optical Coherence Tomography.

Information source: Assistance Publique - H˘pitaux de Paris
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Age-Related Macular Degeneration; Choroidal Vessels; Anastomosis

Intervention: tests (Other)

Phase: N/A

Status: Completed

Sponsored by: Assistance Publique - H˘pitaux de Paris

Official(s) and/or principal investigator(s):
Ramin TADAYONI, MD,PhD, Principal Investigator, Affiliation: Assistance Publique - H├┤pitaux de Paris

Summary

Determination of the sensitivity and specificity of different combinations of imaging techniques (spectral domain optical coherence tomography, fundus photography and fluorescein

angiography) used for the diagnosis of choroidal neovessels complicating age - related

macular degeneration. This information will help to determine the choice of the most suitable combination for the above diagnosis.

Clinical Details

Official title: Evaluation of the Sensitivity and Specificity of Optical Coherence Tomography Combined With Fundus Color Photos for Diagnosis of Choroidal Neovessels in Age-related Macular Degeneration

Study design: Observational Model: Cohort, Time Perspective: Cross-Sectional

Primary outcome: Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photos in the diagnosis of choroidal neovessels in age- related macular degeneration.

Secondary outcome:

Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography in the diagnosis of choroidal neovessels in age - related macular degeneration.

Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography, and of fluorescein angiography combined with fundus color photography.

Rate of unusable images for each technique

Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels

Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels.

Evaluation of the intra-and inter-reader reproducibility of the diagnosis of choroidal neovessels in age-related macular degeneration using fluorescein angiography combined with fundus color photography.

Detailed description: The following combinations will be studied: spectral domain optical coherence tomography (OCT) + fundus photography; fluorescein angiography + fundus photography and the combination of all three techniques (OCT+ fundus photography + fluorescein angiography).The sensitivity and specificity of the latter combination will be assessed by comparison with the results for this combination reported by several readers. Inter- and intra-observer reproducibility of the different combinations will also be studied.

Eligibility

Minimum age: 50 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age> 50 years

- First visit for suspicion of choroidal neo-vessels complicating age related macular

degeneration

- Fundus color photographs , FLUORESCEIN angiography and OCT prescription

Exclusion Criteria:

- Age < 50 years

- Diabetes

- Central vein occlusion Macular hole Epi-retinal membrane Retinal detachment Macular

hemorrhage more than the 1/3 of the lesion

- History of macular laser, PDT or intra-vitreal injection

Locations and Contacts

Additional Information

Starting date: April 2010
Last updated: July 20, 2012

Page last updated: August 20, 2015

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