Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock
Information source: The University of Texas Health Science Center, Houston
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Septic Shock
Phase: N/A
Status: Recruiting
Sponsored by: The University of Texas Health Science Center, Houston Official(s) and/or principal investigator(s):
Rosa M Estrada-Y-Martin, MD, Principal Investigator, Affiliation: The University of Texas-Health Science Center at Houston / Division of Pulmonary, Sleep and Critical Care Medicine
Overall contact:
Rosa M Estrada-Y-Martin, MD, Phone: 713-500-6830, Email: rosa.m.estrada.y.martin@uth.tmc.edu
Summary
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is
considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic
shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine
the level of free serum cortisol.
Clinical Details
Official title: Correlation Between Salivary Cortisol and Free Serum Cortisol Compared to Total Serum Cortisol in MICU Patients With Septic Shock
Study design: Cohort, Prospective
Detailed description:
Free serum cortisol is considered the active hormone.
In patients with septic shock only the total serum cortisol level is available, however, the
free cortisol level can be normal despite a low total cortisol level due to changes in the
serum protein.
The hormone can be replaced improperly in these patients and contribute to poor outcome in
septic shock.
We are studying adult MICU patients with septic shock who are not receiving corticosteroid
replacement.
This study does not include any intervention.
In-hospital or 28-day mortality are registered in all the patients.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adult patients with septic shock
Exclusion Criteria:
- Corticosteroid replacement
- Blood in mouth
Locations and Contacts
Rosa M Estrada-Y-Martin, MD, Phone: 713-500-6830, Email: rosa.m.estrada.y.martin@uth.tmc.edu
The University of Texas- Health Science Center at Houston, Houston, Texas 77030, United States; Recruiting
Rosa M Estrada-Y-Martin, MD, Phone: 713-500-6830, Email: rosa.m.estrada.y.martin@uth.tmc.edu
Rosa M Estrada-Y-Martin, MD, Principal Investigator
Additional Information
Starting date: February 2007
Ending date: June 2008
Last updated: June 4, 2008
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