DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock

Information source: The University of Texas Health Science Center, Houston
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Septic Shock

Phase: N/A

Status: Completed

Sponsored by: The University of Texas Health Science Center, Houston

Official(s) and/or principal investigator(s):
Rosa M Estrada-Y-Martin, MD, Principal Investigator, Affiliation: The University of Texas-Health Science Center at Houston / Division of Pulmonary, Sleep and Critical Care Medicine


The purpose of the study is:

- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is

considered to be almost complete free cortisol) and,

- to correlate free serum cortisol to total serum cortisol levels

Both in patients with septic shock (severe sepsis requiring vasopressors). We believe that:

- total serum cortisol does not correlate with free serum cortisol in patient with septic

shock and,

- that salivary cortisol correlates with free serum cortisol and can be used to determine

the level of free serum cortisol.

Clinical Details

Official title: Correlation Between Salivary Cortisol and Free Serum Cortisol Compared to Total Serum Cortisol in MICU Patients With Septic Shock

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: Salivary cortisol

Detailed description: Free serum cortisol is considered the active hormone. In patients with septic shock only the total serum cortisol level is available, however, the free cortisol level can be normal despite a low total cortisol level due to changes in the serum protein. The hormone can be replaced improperly in these patients and contribute to poor outcome in septic shock. We are studying adult MICU patients with septic shock who are not receiving corticosteroid replacement. This study does not include any intervention. In-hospital or 28-day mortality are registered in all the patients.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Adult patients with septic shock

Exclusion Criteria:

- Corticosteroid replacement

- Blood in mouth

Locations and Contacts

The University of Texas- Health Science Center at Houston, Houston, Texas 77030, United States
Additional Information

Starting date: February 2007
Last updated: December 2, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017