This open-label, multicenter study will evaluate the safety and efficacy of RO5185426 in
patients with BRAF V600 mutation-positive, surgically incurable and unresectable stage IIIC
or IV metastatic melanoma. Eligible patients will receive RO5185426 (960 mg twice daily
orally) until disease progression or unacceptable toxicity occurs, with a safety follow-up
of 24 months after discontinuation of the study drug.
Minimum age: 16 Years.
Maximum age: N/A.
Gender(s): Both.
Tirana 1000, Albania
Buenos Aires C1280AEB, Argentina
Buenos Aires C1425DTG, Argentina
Buenos Aires C1426ANZ, Argentina
Feldkirch 6807, Austria
Graz 8036, Austria
Innsbruck 6020, Austria
Linz 4020, Austria
Salzburg 5020, Austria
St. Pölten 3100, Austria
Wien 1090, Austria
Brussel 1090, Belgium
Bruxelles 1200, Belgium
Wilrijk 2610, Belgium
Banja Luka 78000, Bosnia and Herzegovina
Sarajevo 71000, Bosnia and Herzegovina
Plovdiv 4000, Bulgaria
Sofia 1756, Bulgaria
Bogota, Colombia
Cali, Colombia
Medellin-Antioquia, Colombia
Zagreb 10000, Croatia
Brno 656 53, Czech Republic
Hradec Kralove 500 05, Czech Republic
Olomouc 775 20, Czech Republic
Ostrava 708 52, Czech Republic
Praha, Czech Republic
Praha 128 00, Czech Republic
Aarhus C 8000, Denmark
Herlev 2730, Denmark
Odense 5000, Denmark
Cuenca, Ecuador
Guayaquil EC090104, Ecuador
Portoviejo EC130104, Ecuador
Tallinn 13419, Estonia
Tallinn 11312, Estonia
Tartu 50406, Estonia
Helsinki 00029, Finland
Tampere 33520, Finland
Turku 20520, Finland
Aachen 52074, Germany
Augsburg 86179, Germany
Berlin 12200, Germany
Bochum 44791, Germany
Buxtehude 21614, Germany
Chemnitz 09117, Germany
Dresden 01307, Germany
Düsseldorf 40225, Germany
Erfurt 99089, Germany
Erlangen 91054, Germany
Essen 45122, Germany
Frankfurt 60596, Germany
Freiburg 79104, Germany
Gera 07548, Germany
Göttingen 37075, Germany
Hamburg 20246, Germany
Hannover 30449, Germany
Heidelberg 69115, Germany
Heilbronn 74078, Germany
Jena 07743, Germany
Kassel 34125, Germany
Kiel 24105, Germany
Köln 50937, Germany
Leipzig 04103, Germany
Ludwigshafen 67063, Germany
Lübeck 23538, Germany
Magdeburg 39120, Germany
Mainz 55131, Germany
Mannheim 68167, Germany
Marburg 35043, Germany
Minden 32429, Germany
München 80337, Germany
München 80804, Germany
Münster 48149, Germany
Münster 48157, Germany
Nürnberg 90419, Germany
Quedlinburg 06484, Germany
Recklinghausen 45657, Germany
Regensburg 93053, Germany
Tübingen 72076, Germany
Wiesbaden 65191, Germany
Wuppertal 42283, Germany
Würzburg 97080, Germany
Athens 115 27, Greece
Athens 15123, Greece
Heraklion, Crete 71110, Greece
Piraeus 18547, Greece
Budapest 1122, Hungary
Budapest 1085, Hungary
Debrecen 4012, Hungary
Pecs 7632, Hungary
Szeged 6720, Hungary
Hyderabad 500034, India
Lucknow 226003, India
Mumbai 400012, India
Nashik 422004, India
New Delhi 110085, India
Trivandrum 695 011, India
Vellore 632004, India
Cork, Ireland
Dublin 7, Ireland
Dublin, Ireland
Dublin 4, Ireland
Galway, Ireland
Limerick, Ireland
Waterford, Ireland
Beer Sheva 8410101, Israel
Hafia 3109601, Israel
Jerusalem 91120-01, Israel
Ramat Gan 5262100, Israel
Seoul 110-744, Korea, Republic of
Seoul 120-752, Korea, Republic of
Seoul 135-710, Korea, Republic of
Seoul 137-701, Korea, Republic of
Seoul 138-736, Korea, Republic of
Daugavpils 5417, Latvia
Riga LV 1079, Latvia
Klaipeda 92288, Lithuania
Vilnius 08661, Lithuania
Skopje 1000, Macedonia, The Former Yugoslav Republic of
Leon 37000, Mexico
Mexico City 14000, Mexico
Mexico DF 06726, Mexico
Amsterdam 1081 HV, Netherlands
Amsterdam 1066 CX, Netherlands
Blaricum 1261 AN, Netherlands
Breda 4818 CK, Netherlands
Groningen 9713 GZ, Netherlands
Leiden 2333 ZA, Netherlands
Maastricht 6229 HX, Netherlands
Nijmegen 6500 HB, Netherlands
Rotterdam 3000 CA, Netherlands
Utrecht 3584 CX, Netherlands
Bergen 5021, Norway
Oslo 0379, Norway
Arequipa 04001, Peru
Lima 34, Peru
Krakow 31-531, Poland
Olsztyn 10-228, Poland
Poznań 60-693, Poland
Warszawa 02-781, Poland
Lisboa 1099-023, Portugal
Porto 4200-072, Portugal
Bucuresti 022328, Romania
Cluj-Napoca 400058, Romania
Timisoara 300167, Romania
Krasnodar 350040, Russian Federation
Moscow 115478, Russian Federation
Moscow 143423, Russian Federation
Saint-Petersburg 197022, Russian Federation
Saint-Petersburg 197758, Russian Federation
Stavropol ND, Russian Federation
UFA 450054, Russian Federation
Belgrade 11000, Serbia
Belgrade 11080, Serbia
Bratislava 812 50, Slovakia
Bratislava 833 10, Slovakia
Poprad 058 01, Slovakia
Ljubljana 1000, Slovenia
Bloemfontein 9300, South Africa
Cape Town 7570, South Africa
Cape Town 7700, South Africa
Johannesburg 2196, South Africa
Pretoria 0002, South Africa
Sandton 2196, South Africa
Barcelona 08035, Spain
Barcelona 08036, Spain
Barcelona 08916, Spain
Cordoba 14004, Spain
Granada 18014, Spain
La Coruña 15006, Spain
Leon 24071, Spain
Madrid 28034, Spain
Madrid 28040, Spain
Madrid 28041, Spain
Madrid 28046, Spain
Malaga 29010, Spain
Salamanca 37007, Spain
Sevilla 41009, Spain
Valencia 41014, Spain
Valencia 46009, Spain
Zaragoza 50009, Spain
Goteborg 40036, Sweden
Lund 22185, Sweden
Stockholm 171 76, Sweden
Umeå, Sweden
Uppsala 75185, Sweden
Basel 4031, Switzerland
Bern 3010, Switzerland
Chur 7000, Switzerland
Lausanne 1011, Switzerland
St. Gallen 9007, Switzerland
Zürich 8091, Switzerland
Adana 01120, Turkey
Adana 01330, Turkey
Ankara 06230, Turkey
Ankara 06500, Turkey
Antalya 07000, Turkey
Bornova, İZMİR 35100, Turkey
Gaziantep 27310, Turkey
Istanbul 34000, Turkey
Istanbul 34300, Turkey
Istanbul 34365, Turkey
Izmir 35340, Turkey
Sıhhiye, ANKARA 06100, Turkey
Cambridge CB2 2QQ, United Kingdom
Glasgow G12 0YN, United Kingdom
Guildford GU2 7XX, United Kingdom
Leeds LS9 7TF, United Kingdom
London SW3 6JJ, United Kingdom
Manchester M20 4BX, United Kingdom
Newcastle upon Tyne NE7 7DN, United Kingdom
Northwood HA6 2RN, United Kingdom
Nottingham NG5 1PB, United Kingdom
Oxford OX3 7LJ, United Kingdom
Southampton SO16 6YD, United Kingdom
Swansea SA2 8QA, United Kingdom
Edmonton, Alberta T6G 1Z2, Canada
Oviedo, Asturias 33011, Spain
North Vancouver, British Columbia V7L 2L7, Canada
Vancouver, British Columbia V5Z 4E6, Canada
Napoli, Campania 80131, Italy
Santander, Cantabria 39008, Spain
Meldola, Emilia-Romagna 47014, Italy
Modena, Emilia-Romagna 41100, Italy
Reggio Emilia, Emilia-Romagna 42100, Italy
Udine, Friuli-Venezia Giulia 33100, Italy
Palma De Mallorca, Islas Baleares 07014, Spain
Las Palmas de Gran Canaria, Las Palmas 35016, Spain
Roma, Lazio 00167, Italy
Roma, Lazio 00168, Italy
Genova, Liguria 16132, Italy
Bergamo, Lombardia 24127, Italy
Brescia, Lombardia 25123, Italy
Milano, Lombardia 20132, Italy
Milano, Lombardia 20133, Italy
Milano, Lombardia 20141, Italy
Winnipeg, Manitoba R2H 2A6, Canada
Cartagena (Murcia), Murcia 30202, Spain
Pamplona, Navarra 31008, Spain
North Sydney, New South Wales 2060, Australia
Waratah, New South Wales 2298, Australia
Westmead, New South Wales 2145, Australia
Wodonga, New South Wales 3690, Australia
Halifax, Nova Scotia B3H 1V7, Canada
Hamilton, Ontario L8V 5C2, Canada
London, Ontario N6A 4L6, Canada
Ottawa, Ontario K1H 8L6, Canada
Toronto, Ontario M4N 3M5, Canada
Toronto, Ontario M5G 2M9, Canada
Torino, Piemonte 10126, Italy
Vigo, Pontevedra 36312, Spain
Bari, Puglia 70126, Italy
Montreal, Quebec H3T 1E2, Canada
Quebec City, Quebec G1R 2J6, Canada
Greenslopes, Queensland 4120, Australia
Townsville, Queensland 4812, Australia
Woolloongabba, Queensland 4102, Australia
Rio de Janeiro, RJ 20230-130, Brazil
Porto Alegre, RS 90035-003, Brazil
Sao Paulo, SP 01246-000, Brazil
Sao Paulo, SP 01321-001, Brazil
Sao Paulo, SP 01509-010, Brazil
Palermo, Sicilia 90127, Italy
Adelaide, South Australia 5000, Australia
La Laguna (Tenerife), Tenerife 38320, Spain
Firenze, Toscana 50139, Italy
Pisa, Toscana 50126, Italy
Siena, Toscana 53100, Italy
Terni, Umbria 05100, Italy
Padova, Veneto 35128, Italy
Geelong, Victoria 3220, Australia
Melbourne, Victoria 3002, Australia
Melbourne, Victoria 3004, Australia
Barakaldo, Vizcaya 48903, Spain
Nedlands, Western Australia 6009, Australia