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Study to Evaluate Subclinical Atherosclerosis (an Early Sign of Heart Disease) in Healthy Adult Immigrant Asian Indians

Information source: North Shore Long Island Jewish Health System
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Flow Mediated Doppler (FMD) (Procedure); Nitroglycerin 0.4 mg sublingual (Drug)

Phase: N/A

Status: Withdrawn

Sponsored by: North Shore Long Island Jewish Health System

Official(s) and/or principal investigator(s):
Rajiv Jauhar, MD, Principal Investigator, Affiliation: North Shore-LIJ Health System


Previous research has shown that Asian Indians are at relatively high risk for developing diabetes, heart problems and high blood pressure. The purpose of this study is to evaluate subclinical atherosclerosis (an early sign of heart disease) which may be associated with abnormalities like diabetes mellitus, hypertension (high blood pressure), high cholesterol and heart problems. Endothelium is the inner lining of your blood vessels. Endothelial dysfunction is found more in people with diabetes. In addition, high body mass index (BMI) is a strong risk factor for developing metabolic abnormalities like diabetes mellitus. This research study may provide information as to how useful endothelial dysfunction will be to detect people at risk of metabolic abnormalities and heart disease at an early stage. Two groups of subjects will be enrolled. Caucasians and Asian Indians There will be a total of 100 subjects participating in this study. Approximately 50 Caucasians and 50 Asian Indians will be enrolled. Caucasians will serve as the control group for this study.

Clinical Details

Official title: Assessment of Subclinical Atherosclerosis in Healthy Adult Immigrant Asian Indians Using Flow Mediated Endothelial Dysfunction Method

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Primary outcome: Assessment of subclinical atherosclerosis in healthy adult immigrant Asian Indians using flow mediated endothelial dysfunction method


Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Asian Indians and Caucasians between the ages of 20 and 65 living in the boroughs of

New York City and the Long Island area. Subjects must provide a record of blood results completed within the past year to determine eligibility (hematology and chemistry results). Exclusion Criteria:

- Subjects with major underlying medical problems, including diabetes, hypertension,

coronary artery disease (CAD), hyperlipidemia, systolic blood pressure below 90 mm Hg and liver or kidney disease will be excluded.

Locations and Contacts

Additional Information

Starting date: April 2010
Last updated: June 10, 2013

Page last updated: August 23, 2015

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