Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages
Information source: Ruhr University of Bochum
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Platelet Aggregation
Intervention: dipyrone (Drug); Ibuprofen (Drug); Acetaminophen (Drug); Acetaminophen (Drug); Parecoxib/Valdecoxib (Drug); Blood samples (Other)
Phase: N/A
Status: Completed
Sponsored by: Ruhr University of Bochum Official(s) and/or principal investigator(s): Matthias Schmauss, MD, Principal Investigator, Affiliation: research associate of the Ruhr University Bochum Christoph Maier, Professor, Study Chair, Affiliation: Leader of the Department for Pain Medicine of the University Hospital Bergmannsheil Bochum
Summary
Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of
traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators
conducted the study in comparing patients undergoing traumatologic, visceral or plastic
surgical procedures. The investigators randomized them to four groups receiving common
analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The
investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after
first intake. The investigators compared the aggregation via aggregometry of platelet rich
plasma.
Clinical Details
Official title: Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses
Secondary outcome: Percentage of aggregation of platelet rich plasma 1hour and 4 hours after initiation of study drug
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Planned traumatologic, orthopedic, visceral or plastic surgical procedures
Exclusion Criteria:
- Prior intake of drugs with effect on the platelet aggregation
- Patients with diseases of the gastrointestinal systems
- Patients with cardiac or circulatory diseases
- Patients receiving corticoids
- Patients with cold or asthma
- ASA-classification > 3
Locations and Contacts
BG University Hospital Bergmannsheil GmbH, Bochum 44789, Germany
Additional Information
Starting date: February 2004
Last updated: September 29, 2008
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