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Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Information source: Ruhr University of Bochum
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Platelet Aggregation

Intervention: dipyrone (Drug); Ibuprofen (Drug); Acetaminophen (Drug); Acetaminophen (Drug); Parecoxib/Valdecoxib (Drug); Blood samples (Other)

Phase: N/A

Status: Completed

Sponsored by: Ruhr University of Bochum

Official(s) and/or principal investigator(s):
Matthias Schmauss, MD, Principal Investigator, Affiliation: research associate of the Ruhr University Bochum
Christoph Maier, Professor, Study Chair, Affiliation: Leader of the Department for Pain Medicine of the University Hospital Bergmannsheil Bochum

Summary

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Clinical Details

Official title: Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses

Secondary outcome: Percentage of aggregation of platelet rich plasma 1hour and 4 hours after initiation of study drug

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Planned traumatologic, orthopedic, visceral or plastic surgical procedures

Exclusion Criteria:

- Prior intake of drugs with effect on the platelet aggregation

- Patients with diseases of the gastrointestinal systems

- Patients with cardiac or circulatory diseases

- Patients receiving corticoids

- Patients with cold or asthma

- ASA-classification > 3

Locations and Contacts

BG University Hospital Bergmannsheil GmbH, Bochum 44789, Germany
Additional Information

Starting date: February 2004
Last updated: September 29, 2008

Page last updated: August 23, 2015

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