The purpose of the study is to compare the risk of developing squamous skin cancer (SCC) or
other types of cancer after treatment of AKs with ingenol mebutate gel or imiquimod cream.
Subjects will be randomised to treatment with ingenol mebutate or imiquimod and will receive
a second treatment cycle with the same treatment if the first treatment does not clear all
AKs. Subjects will be followed over a period of three year (36 months) after first treatment
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Maj Britt Larsen, ICTM, Phone: +4572262437, Ext: 2437, Email: maj.larsen@leo-pharma.com
CHU Angers - Service de Dermatologie, Angers 49933, France; Not yet recruiting
Yannick Le Corre, Dr.
Yannick Le Corre, Dr., Principal Investigator
CHU Besançon - Hôpital Jean Minjoz, Besançon 25030, France; Not yet recruiting
Francois Aubin, Prof.
Francois Aubin, Prof., Principal Investigator
HOPITAL AVICENNE - Service de Dermatologie, Bobigny 93009, France; Not yet recruiting
Fréderic Caux, Prof.
Fréderic Caux, Prof., Principal Investigator
CHRU de Brest - Hôpital Morvan - Service de Dermatologie, Brest 29609, France; Not yet recruiting
Laurent Misery, Prof.
Laurent Misery, Prof., Principal Investigator
CHU Albert Michallon - Service de Dermatologie, Pôle Pluridisciplinaire de Médecine, Grenoble 38043, France; Not yet recruiting
Marie-Thérése Leccia, Prof.
Marie-Thérèse Leccia, Prof., Principal Investigator
Hôpital Claude Huriez - CHRU de Lille - Clinique de Dermatologie, Lille 59037, France; Not yet recruiting
Laurent Mortier, Prof.
Laurent Mortier, Prof., Principal Investigator
Hôpital de la Timone - Service de Dermatologie Vénérologie, Marseille 13385, France; Not yet recruiting
Jean-Jacques Grob, Prof.
jean-Jacques Grob, Prof., Principal Investigator
CHU de Nantes - Hôtel Dieu - Unité Fonctionnelle de Dermatologie Cancérologie, Nates 44093, France; Not yet recruiting
Brigitte Dreno, Prof.
Brigitte Dreno, Prof., Principal Investigator
HOPITAL DE L ARCHET II - Service de Dermatologie-Vénérologie, Nice 06202, France; Not yet recruiting
Jean-Philippe Lacour, Prof.
Jean-Philippe Modiano, Prof., Principal Investigator
Hôpital Caremeau, Nimes 30029, France; Not yet recruiting
Laurent Meunier, Prof.
Laurent Meunier, Prof., Principal Investigator
HOPITAL COCHIN TARNIER - Service de Dermatologie, Paris 75006, France; Not yet recruiting
Selim Aractingi, Prof.
Selim Aractingi, Prof., Principal Investigator
Hôpital Saint Louis - Service de Dermatologie, Paris 75475, France; Not yet recruiting
Nicole Basset-Seguin, Prof.
Nicole Basset-Seguin, Dr., Principal Investigator
CHU BORDEAUX - Hôpital Haut-Lévêque, Pessac 33604, France; Not yet recruiting
Marie Beylot-Barry, Prof.
Marie Beylot-Barry, Prof., Principal Investigator
CHU Poitiers - Service de Dermatologie, Poitiers 86021, France; Not yet recruiting
Gérard Guillet, Prof.
Gérard Guillet, Prof., Principal Investigator
C.H.U. de Saint-Etienne - Hôpital Nord, Saint-Etienne 42055, France; Not yet recruiting
Frédéric Cambazard, Prof.
Frédéric Cambazard, Prof., Principal Investigator
Hôpital d'instruction des Armées Bégin - Clinique Dermatologique, St Mandé 94160, France; Not yet recruiting
Michel Dupin, Dr.
Michel Dupin, Dr., Principal Investigator
Hautarztpraxis Simon, Berlin 10827, Germany; Recruiting
M Simon, Dr.med
M Simon, Dr. med., Principal Investigator
Hauttumorzentrum Bochum Universitätsklinikum der Ruhr-Universität-Bochum, Bochum 44791, Germany; Recruiting
N Lahner, Dr. med
N Lahner, Dr. med., Principal Investigator
Praxis Streit Bucholz, Buchholz 21244, Germany; Recruiting
V Streit, Dr. med
V Streit, Dr. med., Principal Investigator
Dermatologisches Zentrum, Am Krankenhaus 1, Buxtehude 21614, Germany; Not yet recruiting
P Mohr, MD
P Mohr, Dr.med, Principal Investigator
Klinikum Dortmund - Hautklinik, Dortmund 44137, Germany; Recruiting
D Nashan, Prof. Dr.med
D Nashan, Prof. Dr.med., Principal Investigator
Mensingderma, Hamburg 22391, Germany; Recruiting
C Mensing, Dr.
C Mensing, Dr., Principal Investigator
Universitätsklinikum Leipzig Klinik für Dermatologie, Venerologie und Allergologie, Leipzig 04103, Germany; Recruiting
J C Simon, Prof. Dr. med.
J C Simon, Prof. Dr.med, Principal Investigator
Hautpraxis Dr. Ina Schulze, Markkleeberg 04416, Germany; Recruiting
I Schulze, Dr.med.
I Schulze, Dr.med., Principal Investigator
Hauttumorzentrum Münster, Münster 48149, Germany; Not yet recruiting
C Weishaupt
C Weishaupt, Dr.med., Principal Investigator
Klinik für Dermatologie und Allergologie, Klinikum Vest, Behandlungszentrum, Knappschaftskrankenhaus Recklinghausen,, Recklinghausen 45657, Germany; Recruiting
R M Szeimies, Prof. Dr.med
R M Szeimies, Prof. Dr.med, Principal Investigator
Universitätklinikum Regensburg, Regensburg 93053, Germany; Not yet recruiting
S Karrer, Prof. Dr.med.
S Karrer, Prof. Dr.med, Principal Investigator
Praxis Dr. Hoffmann, Witten 58453, Germany; Recruiting
M Hoffmann, Dr. med.
M Hoffmann, Dr.med., Principal Investigator
Praxis Derma Hübinger, Wuppertal 42105, Germany; Recruiting
F Hübinger, Dr.med.
F Hübinger, Dr.med., Principal Investigator
Universitätsklinikum Würzburg, Würzburg 97080, Germany; Recruiting
H Hamm, Prof. Dr.
H Hamm, Prof.Dr., Principal Investigator
Hull Royal Infirmary, Hull, United Kingdom; Not yet recruiting
S Walton
S Walton, MD, Principal Investigator
Ninewells Hospital, Dundee, Angus, United Kingdom; Recruiting
C Proby, MD
C Proby, MD, Principal Investigator
Cumberland Infirmary, Carlisle, Cumbria, United Kingdom; Recruiting
M Nik, MD
M Nik, MD, Principal Investigator
Heavitree Hospital, Exeter, Devon, United Kingdom; Recruiting
A Downs
A Downs, MD, Principal Investigator
Brighton General Hospital, Borough of Brighton and Hove, East Sussex, United Kingdom; Recruiting
C DeGiovanni, MD
C DeGiovanni, MD, Principal Investigator
Manchester Royal Infirmary, Manchester, Greater Manchester, United Kingdom; Recruiting
J Lear, MD
J Lear, MD, Principal Investigator
Monklands Hospital, Airdrie, Lanarkshire, United Kingdom; Recruiting
G Gupta, MD
G Gupta, MD, Principal Investigator
Scunthorpe General Hospital, Scunthorpe, Lincolnshire, United Kingdom; Recruiting
A Butt, MD
A Butt, MD, Principal Investigator
Royal Gwent Hospital, Newport, Monmouthshire, United Kingdom; Recruiting
A Anstey, MD
A Anstey, MD, Principal Investigator
Harrogate District Hospital, Harrogate, North Yorkshire, United Kingdom; Not yet recruiting
A M Layton, MD
A M Layton, MD, Principal Investigator
Scarborough Hospital, Scarborough, North Yorkshire, United Kingdom; Recruiting
C Lyon, MD
C Lyon, MD, Principal Investigator
Cannock Chase Hospital, Cannock, Staffordshire, United Kingdom; Recruiting
S Cheung, MD
S Cheung, MD, Principal Investigator
East Surrey Hospital, Redhill, Surrey, United Kingdom; Recruiting
S Cliff, MD
S Cliff, MD, Principal Investigator
Southlands Hospital, Shoreham-by-Sea, West Sussex, United Kingdom; Recruiting
A Woollons, MD
A Woollons, MD, Principal Investigator
St Luke's Hospital, Bradford, West Yorkshire, United Kingdom; Recruiting
A Wright, MD
A Wright, MD, Principal Investigator
Chapel Allerton Hospital, Leeds, West Yorkshire, United Kingdom; Not yet recruiting
M Goodfield, MD
M Goodfield, MD, Principal Investigator