DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



A Study of Inhaled Atropine Sulfate in Healthy Adults

Information source: MicroDose Defense Products L.L.C.
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Organophosphorus Poisoning

Intervention: atropine sulfate (Drug); atropine sulfate (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: MicroDose Defense Products L.L.C.

Official(s) and/or principal investigator(s):
Michael Donahoe, M.D., Principal Investigator, Affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh
Timothy Corcoran, Ph.D., Study Director, Affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh

Summary

MicroDose Defense Products, LLC is developing an atropine dry powder inhaler (ADPI). This pilot study compares the pharmacokinetics (PK) of inhaled dry powder atropine as delivered by the ADPI to atropine delivery from the AtroPen autoinjector.

Clinical Details

Official title: Development of an Inhaled, Dry Powder Delivery System for the Administration of Atropine Sulfate

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: To characterize pharmacokinetic endpoints for atropine dry powder inhalation (Cmax, Tmax, AUC) and compare these to intramuscular pharmacokinetics (Atropen autoinjector)

Secondary outcome: To evaluate the safety and tolerability of atropine dry powder inhalation (Clinical Labs testing, Pulse, Pulse Oximetry, Temperature, Heart Rate, Pulmonary Function Tests, Respiratory Rate, Near Point of Accommodation, Pupil Size).

Eligibility

Minimum age: 18 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Subjects will be 18-55 years of age.

- Subjects will be able to read and comprehend the English language.

Exclusion Criteria:

- Subjects weighing less than 100 lbs.

- Women of childbearing potential who are pregnant or unwilling to undergo pregnancy

testing; females with positive pregnancy testing on either screening day or any test day will be excluded. Nursing mothers will be excluded

- Persons unable or unwilling to complete written informed consent (No proxy consent

will be obtained).

- Persons with a past medical history or symptoms of pulmonary disease (including but

not limited to: asthma, COPD, Emphysema, Sarcoidosis, Lung Cancer, Pulmonary Embolism, Pulmonary Hypertension))or cardiac disease (coronary artery disease, hypertension, angina, arrhythmias, palpitations, past myocardial infarction history).

- Persons with a previous history or symptoms of adverse reaction to atropine.

- Persons with history or symptoms of prostate hypertrophy or prostate cancer.

- Persons with a history or symptoms of pyloric stenosis.

- Persons with a history or symptoms of high blood pressure or a diagnosis of cerebral

vascular accident (CVA) or transient ischemic attack (TIA).

- Subjects with a history or symptoms of urological disorders or renal insufficiency.

- Subjects with a history or symptoms of diabetes.

- Persons demonstrating increased intraocular pressure, an abnormal optical exam, or

history of glaucoma.

- Persons demonstrating a one second forced expiratory volume (FEV1) or a forced vital

capacity (FVC) of less than 70% of predicted either at screening or during pre test exam will be excluded

- Persons demonstrating any kind of irregular heart rhythm during pre test screening

will be excluded. Persons demonstrating any irregular rhythms during testing will be immediately removed. from testing and receive appropriate care and referral from the study physician

- Persons will be excluded if any two laboratory tests characterizing a specific organ

system are more than 10% outside of normal range

- Subjects with screening day vital signs considered to be beyond normal range will be

excluded. This will include BP systolic > 140, Diastolic > 90, HR > 100, RR > 20, temp > 38.

- The study physician will have the discretion to exclude subjects that he/she feels

will not be able to safely able to participate in these studies based on review of all screening materials.

- Self reported tobacco use or positive cotinine testing.

- Any individuals with positive results on a urine drug screening will be excluded.

- Persons with an O2 saturation value < 92%.

- Persons who have performed other medical studies involving drug delivery in the last

30 days.

- Blood donation in the last 30 days.

- Subjects regularly utilizing any of the following medications will be excluded:

amantadine, quinidine, phenothiazines, tricyclic antidepressants, digoxin, potassium chloride and potassium citrate formulations, topiramate, zonisamide.

- Subjects under 18 years of age.

Locations and Contacts

Montefiore Hospital Clinical and Translational Research Center, Pittsburgh, Pennsylvania 15213, United States
Additional Information

Product Description

Starting date: August 2009
Last updated: August 10, 2010

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017