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Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination

Information source: Larissa University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Glaucoma; Ocular Hypertension

Intervention: Bimatoprost and Bimatoprost/Timolol fixed combination. (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Larissa University Hospital


The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma.

Clinical Details

Official title: Efficacy Of The Bimatoprost/Timolol Fixed Combination In Patients Treated With Bimatoprost for Primary Open Angle Glaucoma, Exfoliation Glaucoma or Ocular Hypertension.

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Mean diurnal intraocular pressure


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Primary open angle glaucoma

- Exfoliation glaucoma

- Ocular hypertension

Exclusion Criteria:

- Younger than 18 years old

- Inability to understand and/or follow study requirements

- Women of childbearing potential not using reliable birth control, pregnant or

lactating women

- History of chronic obstructive pulmonary disease, heart failure, 2nd or 3rd AV block

- Anticipated modification of treatment for systemic hypertension during the study


- History of ocular herpes, corneal scarring, conventional or laser surgery or macular


- History of allergy, poor tolerability or poor response to study medication

- Best corrected visual acuity less than 0. 4

- Significant visual field defect (MD<15. 0 dB)

Locations and Contacts

University Eye Clinic, Larissa, Thessaly 41110, Greece
Additional Information

Starting date: July 2009
Last updated: November 29, 2010

Page last updated: August 23, 2015

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