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Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients

Information source: State University of New York at Buffalo
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Opiate Addiction

Intervention: Methadone (Drug); Buprenorphine/naloxone (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: State University of New York at Buffalo

Official(s) and/or principal investigator(s):
Richard D Blondell, MD, Principal Investigator, Affiliation: SUNY Buffalo


The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.

Clinical Details

Official title: A Randomized Controlled Trial Comparing Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Number of Participants Retained in Treatment

Secondary outcome:

Numerical Rating Score for Pain

Numerical Rating Score for Functioning

Self-reported Illicit Opioid Use

Detailed description: The purpose of this randomized clinical trial is to compare methadone with buprenorphine for the treatment of chronic pain among patients who have developed a physical dependence on prescription opiate analgesics that is associated with psychosocial dysfunction (i. e., addiction).


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- chronic back pain

- opioid addiction

- not successful with abstinence

- at least 18 years old

- able to understand spoken English

- live in Western New York State (Erie or Niagara county)

- have health insurance or ability to pay for health care

- no methadone or buprenorphine treatment within past year

- not member of a vulnerable population (e. g., pregnancy, prisoner)

Exclusion Criteria:

- homelessness

- unable to give consent (e. g., dementia, psychosis)

- serious heart or lung disease

- taking a medication that could interact with methadone or buprenorphine

- pregnancy

Locations and Contacts

Erie County Medical Center, Buffalo, New York 14215, United States

Sheehan Memorial Hospital, Buffalo, New York 14203, United States

Additional Information

Starting date: April 2009
Last updated: August 3, 2012

Page last updated: August 23, 2015

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