Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
Information source: Shanghai Municipal Health Bureau
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
Intervention: Fosinopril and Losartan (Drug)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Shanghai Municipal Health Bureau Official(s) and/or principal investigator(s):
Nan Chen, M.D., Study Chair, Affiliation: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Summary
The purpose of this study is to determine whether fosinopril and losartan are effective in
the treatment of patients with Chronic Kidney Disease(CKD) stage 3.
Clinical Details
Official title: Multi-Center,Double-Blind,Randomized,Controlled Clinical Trial of Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Parallel Assignment
Primary outcome: progress to End Stage Renal Diseasedouble of serum creatinine all cause mortality
Secondary outcome: decreased proteinuria
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients aged 18-75 years old
- Roll out secondary renal diseases
- Do not use steroids and immunosuppresive drugs
- ACEI/ARB treated patients should have 7-14 days wash out period，SiDBP< 110mmHg
- Willing and able to comprehend and give written informed consent
- Willing to follow-up regularly
Exclusion Criteria:
- Use steroids and immunosuppresive drugs
- Secondary renal diseases
- Acute cardio-cerebral diseases within 6 months
- Post renal transplantation
- Pregnant/Nursing women
- History of hypersensitivity to ACEI/ARB
- Refuse to join clinical trial
Locations and Contacts
Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Renji Hospital, Shanghai 200001, China
Xinhua Hospital, Shanghai 200092, China
Shanghai 6th people's hospital, Shanghai 200233, China
Zhongshan Hospital, Shanghai 200032, China
Changzheng Hospital, Shanghai 200003, China
Changhai Hospital, Shanghai 200433, China
Shanghai 455 Hospital, Shanghai 200052, China
Shanghai 85 Hospital, Shanghai 200052, China
Huashan, Shanghai 200040, China
Shanghai 1st People's Hospital, Shanghai 200080, China
Huadong Hospital, Shanghai 200040, China
Shanghai East Hospital, Shanghai 200120, China
Shanghai Changning District Centre Hospital, Shanghai 200336, China
Shanghai Yangpu District Centre Hospital, Shanghai 200090, China
Shanghai 10th People's Hospital, Shanghai 200072, China
Tongji Hospital, Shanghai 200065, China
Shanghai 9th People's Hospital, Shanghai 200011, China
Taizhou People's Hospital, Taizhou, Jiangsu 225300, China
The First affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, China
Guangxing Hospital, Hangzhou, Zhejiang 310007, China
Ningbo Lihuili Hospital, Ningbo, Zhejiang 315000, China
Wenling 1st People's Hospital, Wenling, Zhejiang 317500, China
Shaoyifu Hospital, Hangzhou, Zhejiang 310016, China
The 1st Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
Xiangshan People's Hospital, Xiangshan, Zhejiang 315700, China
Additional Information
Starting date: September 2004
Ending date: July 2008
Last updated: November 29, 2007
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