Genetic Determinants of the Response to Salbutamol Among Asthma Patients
Information source: Hadassah Medical Organization
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Asthma
Intervention: Albuterol (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Hadassah Medical Organization Official(s) and/or principal investigator(s):
Yoseph Caraco, MD, Principal Investigator, Affiliation: Hadassah Medical Organization, Jerusalem, Israel
Overall contact:
Yoseph Caraco, MD, Phone: 00 972 2 6778584, Email: caraco@hadassah.org.il
Summary
The response to salbutamol varies greatly among individuals. Data from previous studies
indicate that some of the variability is accounted for by genetic polymorphisms in the gene
encoding for the adrenoceptor subtype β2. The current study was designed to evaluate
variability in the response to salbutamol among recently diagnosed patients who have not been
treated by β2 agonists or corticosteroids.
Lung function tests will be performed prior to and following a single dose administration of
salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including
pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of
salbutamol plasma concentration.
Clinical Details
Official title: Evaluation of Genetic Factors That May Account for Variability in the Response to Salbutamol Among Patients Suffering From Asthma
Study design: Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacokinetics/Dynamics Study
Primary outcome: Change in lung function tests after salbutamol inhalationChange in blood pressure and pulse after salbutamol inhalation
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18 years and older
- Recently diagnosed as asthmatic
Exclusion Criteria:
- Current treatment by β2 agonist
- Current treatment by corticosteroids
- Acute asthma attack
Locations and Contacts
Yoseph Caraco, MD, Phone: 00 972 2 6778584, Email: caraco@hadassah.org.il
Hadassah Medical Organization, Jerusalem 91120, Israel; Recruiting
Arik Tzukert, DMD, Phone: : 00 972 2 6776095, Email: arik@hadassah.org.il
Hadas Lemberg, PhD, Phone: 00 972 2 6777572, Email: lhadas@hadassah.org.il
Yoseph Caraco, MD, Principal Investigator
Additional Information
Starting date: August 1999
Last updated: October 28, 2008
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