Pharmacokinetic and Pharmacodynamic of Rocuronium

Condition(s) targeted: Neuromuscular Blockade

Intervention: Rocuronium Bromide (Drug)

Phase: N/A

Status: Completed

Sponsored by: Pontificia Universidad Catolica de Chile

Official(s) and/or principal investigator(s):
Luis I Cortinez, MD, Study Chair, Affiliation: Ponticia Universidad Católica

The purpose of this study is characterize the dose-effect relationship of rocuronium bromide at the adductor pollicis and masseter muscles using an pharmacokinetic-pharmacodynamic (PKPD) model. The hypothesis is that masseter muscle has a greater sensitivity to the neuromuscular blockers (rocuronium), faster onset and slower recovery profile than the adductor pollicis muscle.

Official title: Pharmacokinetic and Pharmacodynamic of Rocuronium Bromide Measured in Adductor Pollicis and Masseter Muscles.

Study design: Observational Model: Case-Only, Time Perspective: Prospective

Primary outcome:

strength measuring 2 acceleromyograph. One Placed at the masseter muscle and the other one at the adductor pollicis muscle.

Measure blood concentrations after administration rocuronium

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Scheduled for elective surgery under general anesthesia.

Exclusion Criteria:

- Pregnancy.

- Body mass index (BMI) >25 kg/m2.

- Anticipated difficult airway.

- Surgery associated with great volume loss.

- Presence of any neuromuscular, hepatic, renal, cardiac or respiratory disease.

- Previous history of neuromuscular blockade allergy, and/or administration of drugs

known to interfere with neuromuscular blockade

Related publications:

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Saitoh Y, Oshima T, Nakata Y. Acceleromyographic monitoring of neuromuscular block over the orbicularis oris muscle in anesthetized patients receiving vecuronium. J Clin Anesth. 2010 Aug;22(5):318-23. doi: 10.1016/j.jclinane.2009.09.004.

Kitajima O, Suzuki T, Fukano N, Saeki S, Ogawa S, Noda Y. Onset of rocuronium-induced neuromuscular block evaluated subjectively and accerelomyographically at the masseter muscle. J Anesth. 2011 Jun;25(3):376-9. doi: 10.1007/s00540-011-1129-0. Epub 2011 Apr 12.

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Starting date: March 2013
Last updated: February 25, 2015