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Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

Information source: Wenzhou Medical University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Moderate to Severe Dry Eye Syndrome

Intervention: nonsteroid anti-inflammatory drops (Drug); nonsteroid anti-inflammatory drops (Drug); corticosteroids (Drug); artificial tear substitute (Drug)

Phase: N/A

Status: Completed

Sponsored by: Wenzhou Medical University

Official(s) and/or principal investigator(s):
Wei Chen, MD,PhD, Principal Investigator, Affiliation: Eye Hospital, Wenzhou Medical College, China

Summary

This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients. And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.

Clinical Details

Official title: Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: tear osmolarity

Secondary outcome:

corneal staining

Schirmer test(without anaesthesia)

tear film breakup time(TBUT)

meibomian gland function

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- moderate to severe dry eye syndrome

- tear film breakup time >0 second and ≤5 seconds,or schirmer test(no

anaesthesia)≥2mm/5min and ≤5mm/5min

- corneal staining≥3 scores

Exclusion Criteria:

- allergic to any composition of the drugs under experiment

- previous use of anti-inflammatory drugs or immunosuppressive agent

- viral,bacterial or fungal infection of the eye

- eyelid anomaly

- glaucoma or high IOP

- significant meibomian gland dysfunction

Locations and Contacts

Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China
Additional Information

Starting date: March 2012
Last updated: January 2, 2014

Page last updated: August 20, 2015

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