Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease
Information source: Wenzhou Medical University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Moderate to Severe Dry Eye Syndrome
Intervention: nonsteroid anti-inflammatory drops (Drug); nonsteroid anti-inflammatory drops (Drug); corticosteroids (Drug); artificial tear substitute (Drug)
Phase: N/A
Status: Completed
Sponsored by: Wenzhou Medical University Official(s) and/or principal investigator(s): Wei Chen, MD,PhD, Principal Investigator, Affiliation: Eye Hospital, Wenzhou Medical College, China
Summary
This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have
therapeutic effect on moderate to severe dry eye patients. And compare the efficacy of the
two nonsteroid anti-inflammatory drops with topical corticosteroids.
Clinical Details
Official title: Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: tear osmolarity
Secondary outcome: corneal stainingSchirmer test(without anaesthesia) tear film breakup time(TBUT) meibomian gland function
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- moderate to severe dry eye syndrome
- tear film breakup time >0 second and ≤5 seconds,or schirmer test(no
anaesthesia)≥2mm/5min and ≤5mm/5min
- corneal staining≥3 scores
Exclusion Criteria:
- allergic to any composition of the drugs under experiment
- previous use of anti-inflammatory drugs or immunosuppressive agent
- viral,bacterial or fungal infection of the eye
- eyelid anomaly
- glaucoma or high IOP
- significant meibomian gland dysfunction
Locations and Contacts
Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China
Additional Information
Starting date: March 2012
Last updated: January 2, 2014
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