To compare the rate and extent of absorption of doxycycline tablet (Par) versus doxycycline
capsule (Monodox)(Oclassen).
Inclusion Criteria:
- Male or non-childbearing potential female, smoker or non-smokers
- 18 years of age and older
- Non-childbearing potential female subjects is defined as post-menopausal state:
absence of menses for 12 months prior to drug administration or hysterectomy with
bilateral oophorectomy, or tubal ligation at least 6 months prior to drug
administration
- Capable of consent
Exclusion Criteria:
- Clinically significant illnesses within 4 weeks of the administration of study
medication
- Clinically significant surgery within 4 weeks prior to the administration of the study
medication
- Any clinically significant abnormality found during medical screening
- Any reason which, in the opinion of the medical subinvestigator, would prevent the
subject from participating in the study
- Abnormal laboratory tests judged clinically significant
- Positive testing for hepatitis B, hepatitis C or HIV at screening
- ECG abnormalities or vital sign abnormalities at screening
- BMI greater than or equal to 30. 0 kg/m2
- History of significant alcohol abuse within six months of the screening visit or any
indication of the regular use of more than fourteen units of alcohol per week
- History of drug abuse or use of illegal drugs: soft drugs (marijuana) within 3 months
prior to the screening visit or hard drugs (cocaine, PCP, crack) within 1 year prior
to the screening visit or positive urine drug screen at screening
- History of allergic reactions to heparin, doxycycline, or other related drugs
- Use of any drugs known to induce or inhibit hepatic drug metabolism within 30 days
prior to administration of the study medication
- Use of an investigational drug or participation in an investigational study, within 30
days prior to administration of the study medication.
- Clinically significant history or presence of any clinically significant
gastrointestinal pathology, unresolved gastrointestinal symptoms, liver or kidney
disease, or other conditions known to interfere with the absorption, distribution,
metabolism, or excretion of the drug
- Any clinically significant history or presence of clinically significant neurological,
endocrinal, cardiovascular, pulmonary, hematologic, immunologic, psychiatric, or
metabolic disease
- Use of prescription medication within 14 days prior to administration of study
medication or over-the-counter products within 7 days prior to administration of study
medication, except for topical products without systemic absorption
- Difficulty to swallow study medication
- Smoking more than 25 cigarettes per day Any food allergy, intolerance, restriction or
special diet that, in the opinion of the Medical Sub-Investigator, could
contraindicate the subject's participation in the study A depot injection or an
implant of any drug within 3 months prior to administration of study medication
- Donation of plasma (500 mL) within 7 days prior to drug administration. Donation or
loss of whole blood (excluding the volume of blood that will be drawn during the
screening procedures of this study)prior to the administration of the study medication
(50 mL to 300 mL of whole blood within 30 days, 301 mL to 500 mL of whole blood within
45 days, or more than 500 mL of whole blood within 56 days prior to drug
administration)
- History or presence of clinically significant gastro-oesophageal reflux, stomach
ulcers, or indigestions
- History or presence of clinically significant severe renal or hepatic dysfunction
- History or presence of clinically significant myasthenia gravis
- Breast-feeding subject
- Positive urine pregnancy screen
