This is study of LMC, phenylephrine, and placebo in subjects with SAR. There are three
visits: At Visit 1, subjects will be evaluated for participation and, if they qualify, will
attend Visit 2 for priming. At Visit 2, ragweed pollen will be fed continuously and
dispensed into the environmental exposure unit to induce an allergic reaction. Pollen counts
will be monitored and recorded. During the priming visit(s), subjects will be evaluated
to determine if they qualify. If qualified, they will return for Visit 3, where ragweed
pollen will be fed continuously and dispensed into the environmental exposure unit to induce
an allergic reaction. Pollen counts will be monitored and recorded as in the Priming
Session. Subjects will complete symptom evaluations and if qualified, they will receive
study medication and remain in the environmental exposure unit where symptoms will be
evaluated for 8 hours after dosing. PNIF will be evaluated only during the treatment
session. Four nasal symptoms (rhinorrhea, nasal congestion, sneezing, and nasal itching) and
three non-nasal symptoms (itching/burning eyes, tearing/watery eyes, and itching of
ears/palate) will be evaluated. Adverse events will be collected throughout the study to
assess safety and tolerability, and vital signs will be collected at Visit 1 and at the end
of Visit 3.
Inclusion Criteria:
- Ages 18 years or greater, of either sex, any race.
- A history of SAR due to ragweed for at least two consecutive ragweed seasons, as
diagnosed by the investigator, another physician, or subject-provided history.
- Positive skin prick test to ragweed allergen to be used in the EEU, unless previously
done within 12 months
- Minimum scores (diary evaluation time) must be achieved during pollen exposure during
both a Priming Visit and the Treatment Visit:
- A negative urine pregnancy test at Screening and prior to randomization at the
Treatment Visit for all female subjects of childbearing potential.
- Use of a medically accepted method of birth control.
- In the judgment of the investigator, good health and freedom from any clinically
significant disease (other than SAR) that would interfere with the study schedule or
procedures, or compromise the subject’s safety.
- The appropriate washout times from the prohibited medications.
Exclusion Criteria:
- Pregnancy, intention of becoming pregnant, or lactation.
- A situation or any condition that, in the opinion of the investigator, may interfere
with optimal participation in the study.
- Use of any investigational drugs, including placebo, within 30 days of Screening and
for the duration of the study.
- Current participation in any other clinical study.
- Staff personnel directly involved with this study.
- Dependence (in the opinion of the investigator) upon nasal, oral, or ocular
decongestants, nasal topical antihistamines, or nasal steroids.
- Nasal structural abnormalities, including large nasal polyps or marked septal
deviation, that cause greater than 50% obstruction of nasal airflow.
- Previous enrollment (ie, signed informed consent) into this study.
- History of rhinitis medicamentosa.
- A history of anaphylaxis or severe or serious reaction to skin testing.
- A known potential for hypersensitivity, allergy, or idiosyncratic reaction to the
study drugs or excipients.
- Narrow-angle glaucoma, increased intraocular pressure, urinary retention,
hypertension, severe coronary artery disease, ischemic heart disease, diabetes
mellitus, hyperthyroidism, renal impairment, or prostatic hypertrophy; current
treatment with monoamine oxidase (MAO) inhibitors.
- An upper or lower respiratory tract infection within 28 days (4 weeks) before Priming
(Visit 2) and thereafter.).
- History of a positive test for HIV, TB (not due to vaccination), and hepatitis B (not
due to vaccination) or C.
- Asthma that requires medication other than occasional (<= 3 uses per week) use of an
inhaled short-acting beta-2 agonist.
