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PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

Information source: Danish Headache Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Headache; Migraine

Intervention: PGI2 (Drug)

Phase: Phase 1

Status: Terminated

Sponsored by: Danish Headache Center

Official(s) and/or principal investigator(s):
Troels Wienecke, MD, Principal Investigator, Affiliation: Danish Headache Center

Summary

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind

Primary outcome: Headache

Secondary outcome: rCBF, blood flow, diameter of STA/RA, HR, BP

Eligibility

Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy volunteers,

Exclusion Criteria:

- Primary headache,

- headache on the day of investigation,

- Hypertension,

- hypotension,

- pregnant/nursing

- Daily intake of medication (except oral contraceptives)

- Cardiovascular or CNS disease

- Drug/Alcohol abuse

- Psychiatric disease

Locations and Contacts

Danish Headache Center, Glostrup DK-2600, Denmark
Additional Information

Starting date: September 2005
Last updated: October 25, 2006

Page last updated: August 23, 2015

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