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The Amputation Surgical Site Infection Trial (ASSIT)

Information source: University of Hull
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Wound Infection; Amputation Wound

Intervention: Co-amoxiclav (Drug); Iodine (Drug); Metronidazole (Drug); Chlorhexidine (Drug); Teicoplanin (Drug); Clindamycin (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: University of Hull

Overall contact:
Panos Souroullas, MBChB, Phone: 00447748492992, Email: panos.souroullas@hey.nhs.uk


- Lower limb amputations are performed usually as a last resort in patients with acute

and chronic limb ischaemia (CLI) caused by vascular disease, poorly controlled diabetes or, infection.

- In the period 2003-2008 there were approximately 5,000 amputations per year in the UK.

- The Centre for Disease Control defines a Surgical Site Infection (SSI) as an infection

within 30 days of an operation or up to one year if an implant is left in place and the infection is related to an operative procedure.

- Figures from the Surgical Site Infection Surveillance reported that the highest rate of

surgical site infection was reported in association with lower limb amputation at 13. 1%.

- There is a clear under-representation and the infection rate within our institution is

approximately 25% which reflects the infection rate reported in a recent trial by Sadat et al (22. 5%)

- Prevention of surgical site infections is of paramount importance to patients,

healthcare providers and policy-makers, as they impact on morbidity and mortality and have significant time and cost implications.

- Currently there is NO CONSENSUS as to what the best practice is towards antibiotic

administration in such patients. From a questionnaire-based audit we performed including vascular departments across the entire country, practice varies in both course duration (single dose → 5 days antibiotic course) as well as choice of antibiotics.

- The guideline at our institution suggests the 5-day course of antibiotic prophylaxis.

The course duration varies depending on the clinical picture as well as microbiology results and recommendations.

- There are no randomised control trials that have investigated this aspect of patient

care. We have set up one such trial and through it, we are looking to establish a standard practice which will hopefully be as beneficial as possible to the patient but also cost-effective for NHS.

Clinical Details

Official title: A Randomised Control Trial to Determine Whether a 5 Day Course of Antibiotics is More Clinically and Cost Effective Than a 24 Hour Prophylactic Course for the Prevention of Surgical Site Infection Following Lower Limb Amputation

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Surgical Site Infection

Secondary outcome:

Impact of different skin preparations on infection rates

Rate of re-intervention


Satisfactory healing rates

Quality of life

Resource use

• Rate of C. Diff., MSSA (Methicillin Sensitive Staphylococcus Aureus), MRSA (Methicillin Resistant Staphylococcus Aureus) infection


Pain Control

Detailed description: As above


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: 1. Adults ≥18 yrs undergoing lower limb amputations who are able to consent to the trial. 2. Able to understand the Patient Information Sheet and capable and willing to give informed consent and follow the protocol requirements (including attending all follow-up visits) Exclusion Criteria: 1. Allergies to chlorhexidine/ alcohol/ iodophors 2. Inability to give informed consent 3. Patients who are admitted to hospital with severe sepsis secondary to gas gangrene requiring multiple operations and admission to Intensive Care Unit. 4. Aged under 18 years at the time of recruitment 5. Use of investigational drug/device therapy within preceding 4 weeks that may interfere with this study. 6. Toe amputations

Locations and Contacts

Panos Souroullas, MBChB, Phone: 00447748492992, Email: panos.souroullas@hey.nhs.uk

Hull Royal Infirmary, Hull HU3 2JZ, United Kingdom; Recruiting
Panos Souroullas, MBChB, MRCS, Phone: 00447748492992, Email: panos.souroullas@hey.nhs.uk
Panos Souroullas, MBChB, MRCS, Principal Investigator
Additional Information

Starting date: October 2013
Last updated: December 14, 2014

Page last updated: August 23, 2015

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