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Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation

Information source: Mie University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Adrenal Tumors

Intervention: Radiofrequency ablation (Procedure)

Phase: Phase 2/Phase 3

Status: Completed

Sponsored by: Mie University

Official(s) and/or principal investigator(s):
Koichiro Yamakado, MD, Study Chair, Affiliation: Mie University School of Medicine


The purpose of this study is to evaluate changes in adrenal hormones during adrenal radiofrequency (RF) ablation.

Clinical Details

Official title: Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation

Study design: Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Increase in Catecholamine

Serum Cathecholamine Levels

Number of Participants With Hypertension During Adrenal or Non-adrenal Radiofrequency Ablation

Secondary outcome: Increase in Cortisol

Detailed description: Adrenal radiofrequency (RF) ablation has been increasingly used for the treatment of unresectable adrenal tumors. But one of the major complication is a increase in blood pressure. Hormonal release during RF ablation is considered the cause of hypertension. But there has been no evidence that adrenal hormones affects changes in blood pressure. In this prospective study, we evaluate the changes in adrenal hormones during RF ablation and clarify the cause of hypertensive crisis.


Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Unresectable adrenal tumor which will be treated by radiofrequency (RF)ablation

- Blood pressure is 140mmHg or less before RF ablation

- Age of 20-years or more

- Performance status of 0 or 1

- Agreement from the patient

Exclusion Criteria:

- Platelet count of 50,000/mm^3 or International normalized ratio (INR)>1. 5

Locations and Contacts

Mie University, Tsu, Mie 514-8507, Japan

Mie University Hospital, Tsu, Mie 514-8507, Japan

Additional Information

Starting date: October 2009
Last updated: April 6, 2015

Page last updated: August 20, 2015

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