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Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia

Information source: Yangzhou No.1 People's Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Fasciculation

Intervention: Cisatracurium (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Yangzhou No.1 People's Hospital

Summary

The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.

Clinical Details

Official title: Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: The presence of fasciculations

Secondary outcome:

Side effects of the pretreatment of cisatracurium

The time to maximal depression of twitch

The extent to maximal depression of twitch

The time for twitch recovery to 20% of its control value

The grades of endotracheal intubation

The changes of serum potassium

Myalgia at 24 hours postoperatively

Detailed description: Purpose: To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia. Methods: Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0. 005, 0. 01, and 0. 02 mg/kg cisatracurium, respectively. General anesthesia was induced 3. 5 min later, train of four stimulation was monitored 4. 5 min later, succinylcholine 1. 5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6. 5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before the induction, at the time of endotracheal intubation, and 5 min after intubation were recorded.

Eligibility

Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- American Standards Association (ASA) physical status I or II patients scheduled for

elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia

- 20 - 65 years old

- without acid-base imbalance and electrolyte disturbance

- with normal hepatic and renal function

Exclusion Criteria:

- Patients with known hyperkalemia

- Patients with increased intraocular pressure

- Patients with increased intracranial pressure

- Patients with symptoms of gastroesophageal reflux

- Patients with anticipated airway difficulties

- Patients with malignant fever

- Patients with neuromuscular disease

- Patients with burn or crush injuries

- Patients with taking drugs known to alter the action of neuromuscular blockers

- Patients with with a body mass index exceeding 30

Locations and Contacts

Additional Information

Starting date: March 2013
Last updated: June 22, 2015

Page last updated: August 23, 2015

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