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Pharmacokinetics of Selected Antiinfectives During Sustained Low-efficiency Dialysis (SLED)

Information source: Universitätsklinikum Hamburg-Eppendorf
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Replacement Therapy, Renal

Intervention: Pharmacokinetic Analysis (Other)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Universitätsklinikum Hamburg-Eppendorf

Official(s) and/or principal investigator(s):
Stefan Kluge, Prof. Dr., Principal Investigator, Affiliation: University Medical Center Hamburg-Eppendorf, Department of Intensive Care

Summary

In a prospective, non-interventional, monocentric observational study the pharmacokinetic properties of selected antiinfective drugs during sustained low-efficiency dialysis (SLED) will be analyzed. Plasma specimens will be quantified using high Performance liquid chromatography (HPLC). Primary endpoint: Plasma levels of antiinfectives during SLED Secondary endpoints:

- 28-day-mortality

- length of stay at the intensive care unit (ICU) and in hospital

- clinical and microbiological cure of infections

Inclusion criteria:

- age: > 18 years

- patients under SLED

- antiinfective treatment

exclusion criteria:

- missing informed consent

Clinical Details

Official title: Pharmacokinetics of Selected Antiinfectives During Sustained Low-efficiency Dialysis (SLED)

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: Serum levels of meropenem or ceftazidim during SLED

Secondary outcome:

28-day mortality, for inpatients

Length of stay at the ICU and in hospital

Clinical and microbiological cure of infections

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age: 18 or older

- patients receiving SLED and either meropenem or ceftazidim

Exclusion Criteria:

- missing informed consent

Locations and Contacts

University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
Additional Information

Starting date: July 2013
Last updated: May 4, 2015

Page last updated: August 23, 2015

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