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Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients

Information source: Tang-Du Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Confusion

Intervention: Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium (Drug); Dexmedetomidine (Drug); Normal saline (Drug); Maintenance of anesthesia , propofol, remifentanil,vecuronium (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Tang-Du Hospital

Summary

This study is to explore the effects of dexmedetomidine on postoperative cognitive dysfunction during one-lung ventilation in elder patients.

Clinical Details

Official title: Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients -a Single-center, Randomized ,Double-blinded and Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Primary outcome:

The change in memory

Cognitive function

Postoperative anxiety

Secondary outcome:

Heart rate

Bleeding volume

Total volume of fluid

Duration of one lung ventilation

The total dose of anaesthetic drugs

The total dose of analgesic drugs

Blood pressure

Oxygen saturation

End-tidal carbon dioxide

Operation duration

Eligibility

Minimum age: 55 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Written informed consent.

- Ongoing one-lung ventilation surgery.

- American Society of Anesthesiologists class I to III.

- Aged between 55 and 75 years old.

- Body Mass Index between 18 and 25 kg/m2.

Exclusion Criteria:

- Systolic blood pressure more than 180 mmHg or lower than 90 mmHg,diastolic blood

pressure more than 110 mmHg or lower than 60 mmHg.

- Serious heart,liver,kidney, pulmonary, and endocrine disease or serious infection.

- Suspected or confirmed difficult airway.

- History of abnormal anesthesia.

- Suspected of malignant hyperthermia.

- Use of sedative and antidepressant drug or serious alcoholism

- Mini-mental State Examination less than 17.

- Highest academic degree below grade 6 in primary schools

- Patients inability to exchange with serious visual and hearing impairment or mental

disability.

- History of shock.

- Carotid artery stenosis and central nervous system disease such as stroke, epilepsy.

- Allergic to investigational products or with other contraindication.

- Participated in other study within 30 days .

Locations and Contacts

Additional Information

Starting date: July 2014
Last updated: July 9, 2014

Page last updated: August 23, 2015

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