Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients
Information source: Tang-Du Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postoperative Confusion
Intervention: Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium (Drug); Dexmedetomidine (Drug); Normal saline (Drug); Maintenance of anesthesia , propofol, remifentanil,vecuronium (Drug)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: Tang-Du Hospital
Summary
This study is to explore the effects of dexmedetomidine on postoperative cognitive
dysfunction during one-lung ventilation in elder patients.
Clinical Details
Official title: Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients -a Single-center, Randomized ,Double-blinded and Controlled Trial
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Primary outcome: The change in memoryCognitive function Postoperative anxiety
Secondary outcome: Heart rateBleeding volume Total volume of fluid Duration of one lung ventilation The total dose of anaesthetic drugs The total dose of analgesic drugs Blood pressure Oxygen saturation End-tidal carbon dioxide Operation duration
Eligibility
Minimum age: 55 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Written informed consent.
- Ongoing one-lung ventilation surgery.
- American Society of Anesthesiologists class I to III.
- Aged between 55 and 75 years old.
- Body Mass Index between 18 and 25 kg/m2.
Exclusion Criteria:
- Systolic blood pressure more than 180 mmHg or lower than 90 mmHg,diastolic blood
pressure more than 110 mmHg or lower than 60 mmHg.
- Serious heart,liver,kidney, pulmonary, and endocrine disease or serious infection.
- Suspected or confirmed difficult airway.
- History of abnormal anesthesia.
- Suspected of malignant hyperthermia.
- Use of sedative and antidepressant drug or serious alcoholism
- Mini-mental State Examination less than 17.
- Highest academic degree below grade 6 in primary schools
- Patients inability to exchange with serious visual and hearing impairment or mental
disability.
- History of shock.
- Carotid artery stenosis and central nervous system disease such as stroke, epilepsy.
- Allergic to investigational products or with other contraindication.
- Participated in other study within 30 days .
Locations and Contacts
Additional Information
Starting date: July 2014
Last updated: July 9, 2014
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