The purpose of this study is to assess the effect of multiple doses of esomeprazole on the
pharmacokinetics of isavuconazole. In addition, safety and tolerability of isavuconazole
alone and in combination with esomeprazole will be assessed
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Inclusion Criteria:
- The subject has a body weight of at least 50 kg and a body mass index of 18. 5 to 32
kg/m2, inclusive
- The subject's 12-lead electrocardiogram (ECG) is normal
- The subject's clinical laboratory test results are within normal limits
Exclusion Criteria:
- The subject has any history or evidence of any clinically significant cardiovascular,
gastrointestinal, endocrinologic, hematologic, hepatic, immunologic, metabolic,
urologic, pulmonary, neurologic, dermatologic, psychiatric, renal, and/or other major
disease or malignancy
- The subject has a history of bowel obstruction, swallowing disorder, severe
gastro-intestinal disorders, major gastrointestinal surgery, gastric/duodenal ulcers
or any other condition that may interfere with study drug absorption
- Female subject has been pregnant within 6 months before screening or breast feeding
within 3 months before screening
- The subject has a history of unexplained syncope, cardiac arrest, unexplained cardiac
arrhythmia or torsade de pointes, structural heart disease, or family history of
either Short or Long QT syndrome (suggested by sudden death of a close relative at a
young age due to possible or probable cardiac causes). QT is the time between the
start of the Q wave and the end of the T wave in the heart's electrical system
- The subject has/had febrile illness or symptomatic, viral, bacterial (including upper
respiratory infection), or fungal (non-cutaneous) infection within 1 week prior to
clinic admission
- The subject has received a vaccination within the last 30 days prior to study drug
administration
- The subject has a positive serology test for Hepatitis B surface antigen (HBsAg),
Hepatitis A Immunoglobulin M antibody (anti HAV (IgM)), Hepatitis C antibody
(anti-HCV), or human immunodeficiency virus (anti-HIV 1+2)
- The subject has a known or suspected allergy to any of the components of the trial
products or the azole class of compounds, or a history of multiple and/or severe
allergies to drugs or foods, or a history of severe anaphylactic reactions
- The subject has used tobacco or nicotine containing products in the last 6 months
- The subject has had treatment with any prescribed or non-prescribed drugs (including
vitamins, natural and herbal remedies, e. g. St. John's wort) in the 2 weeks prior
with the exception of hormonal methods of contraception, hormone replacement therapy,
or occasional use of acetaminophen up to 2 g/day
- The subject has participated in any interventional clinical study or has received any
investigational drugs within past 30 days or 5 half-lives, whichever is longer
- The subject has had any significant blood loss, donated one unit (450 mL) of blood or
more, or received a transfusion of any blood or blood products within 60 days or
donated plasma within 7 days prior to clinic admission
- The subject anticipates an inability to abstain from alcohol or caffeine use for 48
hours prior and throughout the duration of the study; or from grapefruit, grapefruit
juice, star fruit, or Seville oranges or any products containing these items from 72
hours prior and throughout the duration of the study
- The subject has history of consuming more than 14 units of alcoholic beverages per
week within 6 months prior to screening or has a history of alcoholism or
drug/chemical/substance abuse within past 2 years prior to screening (Note: one unit
= 12 ounces of beer, 4 ounces of wine or 1 ounce of spirits/hard liquor) or the
subject tests positive for alcohol or drugs of abuse (amphetamines, barbiturates,
benzodiazepines, cannabinoids, cocaine, and opiates)
- The subject has taken part in strenuous exercise within 3 days before Day 1