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Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects

Information source: University of Basel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Memory Functions

Intervention: Salbutamol (Drug); Placebo (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Prof. Dominique de Quervain, MD

Official(s) and/or principal investigator(s):
Dominique de Quervain, Prof. MD, Study Director, Affiliation: University of Basel


Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and cognitive functions in healthy humans.

Clinical Details

Official title: Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome:

Change of emotional memory functions under Salbutamol

Change of episodic memory functions under Salbutamol

Secondary outcome:

Change of emotional state under salbutamol

change of attention functions under salbutamol


Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.


Inclusion Criteria: Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2, normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking, caucasian (European ancestry), able and willing to give written informed consent and comply with the requirements of the study protocol, willing to donate saliva sample for

DNA-analysis -

Exclusion Criteria: Acute or chronic psychiatric or somatic disorder, tachycardia at rest (> 100 bpm), known hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term medication within last 3 months (oral contraceptives are disregarded) smoking (>3 cigarettes per day), concurrent participation in another study, participation in one of our previous studies using the same memory tests, inability to read and understand the

participant's information. -

Locations and Contacts

University of Basel, Division of Cognitive neuroscience, Basel 4055, Switzerland
Additional Information

Starting date: October 2013
Last updated: December 15, 2014

Page last updated: August 23, 2015

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