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SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation

Information source: University Health Network, Toronto
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Liver Failure

Intervention: Rocuronium (Drug)

Phase: N/A

Status: Completed

Sponsored by: University Health Network, Toronto

Official(s) and/or principal investigator(s):
Marcin Wasowicz, MD, Principal Investigator, Affiliation: Toronto General Hospital, University Health Network


Standard anesthetic management of liver transplantation patients includes a general anesthetic using multiple drugs, including the neuromuscular relaxant rocuronium. Pharmacokinetic modelling of this agent has been poorly described during liver transplantation, which impacts on appropriate dosing of this agent within this population where plasma concentrations can vary with fluid shifts and hepatic drug metabolism during the various phases of liver transplantation. Plasma drug and drug metabolite concentrations will be measured using the technique of solid phase micro-extraction (SPME). Measuring and correlating the levels of rocuronium and other liver metabolites with the degree of post transplantation hepatic dysfunction may serve as a simple and cost-effective marker to aid diagnosis, identify those at risk of hepatic dysfunction and potentially grade the severity

Clinical Details

Official title: The Use Of Solid Phase Micro Extraction For Metabolomic Profiling And Concomitant Measurements Of Rocuronium Bromide Levels In Recipients Of Orthotopic Liver Transplantations

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: Plasma drug and drug metabolite concentrations


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- First time liver transplant recipients above 18 years of age

- Elective cadaveric or living donor liver transplant patients will be recruited

Exclusion Criteria:

- All patients under 18 years of age

- Unable to give consent

Locations and Contacts

Toronto General Hospital, Toronto, Ontario, Canada
Additional Information

Starting date: September 2011
Last updated: April 23, 2015

Page last updated: August 23, 2015

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