SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation
Information source: University Health Network, Toronto
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Liver Failure
Intervention: Rocuronium (Drug)
Phase: N/A
Status: Completed
Sponsored by: University Health Network, Toronto Official(s) and/or principal investigator(s):
Marcin Wasowicz, MD, Principal Investigator, Affiliation: Toronto General Hospital, University Health Network
Summary
Standard anesthetic management of liver transplantation patients includes a general
anesthetic using multiple drugs, including the neuromuscular relaxant rocuronium.
Pharmacokinetic modelling of this agent has been poorly described during liver
transplantation, which impacts on appropriate dosing of this agent within this population
where plasma concentrations can vary with fluid shifts and hepatic drug metabolism during
the various phases of liver transplantation. Plasma drug and drug metabolite concentrations
will be measured using the technique of solid phase micro-extraction (SPME). Measuring and
correlating the levels of rocuronium and other liver metabolites with the degree of post
transplantation hepatic dysfunction may serve as a simple and cost-effective marker to aid
diagnosis, identify those at risk of hepatic dysfunction and potentially grade the severity
Clinical Details
Official title: The Use Of Solid Phase Micro Extraction For Metabolomic Profiling And Concomitant Measurements Of Rocuronium Bromide Levels In Recipients Of Orthotopic Liver Transplantations
Study design: Observational Model: Cohort, Time Perspective: Prospective
Primary outcome: Plasma drug and drug metabolite concentrations
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- First time liver transplant recipients above 18 years of age
- Elective cadaveric or living donor liver transplant patients will be recruited
Exclusion Criteria:
- All patients under 18 years of age
- Unable to give consent
Locations and Contacts
Toronto General Hospital, Toronto, Ontario, Canada
Additional Information
Starting date: September 2011
Last updated: April 23, 2015
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