Short and Long Term Efficacy of Combined Cabergoline and Octreotide Treatment in Acromegalic Patients
Information source: Federal University of São Paulo
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Acromegaly
Intervention: cabergoline (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Federal University of São Paulo Official(s) and/or principal investigator(s): Julio Abucham, PhD, Study Director, Affiliation: Federal University of São Paulo
Summary
In acromegaly, nearly 40% of patients fail to control GH/IGF-I levels with somatostatin
analogues (SA). Dopaminergic agonists (DA) are even less effective, but combination therapy
with SA and DA normalizes IGF-I levels in 33-56% of patients in short-term studies. This
study was designed to evaluate short and long term efficacy of cabergoline in controlling
IGF-I levels in acromegalic patients receiving octreotide.
Clinical Details
Official title: Short and Long Term Efficacy of Combined Treatment in Controlling IGI-I Levels in Acromegaly
Study design: Observational Model: Case-Only, Time Perspective: Prospective
Primary outcome: Control of IGF-I levels
Secondary outcome: control IGI-I levels
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Active disease, under octreotide treatment at least 9 months
Exclusion Criteria:
- Cabergoline allergy
Locations and Contacts
Federal University of Sao Paulo, Sao Paulo, SP 04039030, Brazil
Additional Information
Related publications: Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem. 2000 Mar 17;275(11):7862-9. Holdaway IM, Rajasoorya RC, Gamble GD. Factors influencing mortality in acromegaly. J Clin Endocrinol Metab. 2004 Feb;89(2):667-74. Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D, Chanson P, Laws E, Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly Consensus Group. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009 May;94(5):1509-17. doi: 10.1210/jc.2008-2421. Epub 2009 Feb 10. Review.
Starting date: May 2005
Last updated: November 16, 2009
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