Phase II Trial of Enbrel in Patients With Primary Systemic Amyloidosis

Condition(s) targeted: Primary Systemic Amyloidosis

Intervention: Enbrel (Drug)

Phase: Phase 2

Status: Suspended

Sponsored by: The Cleveland Clinic

Official(s) and/or principal investigator(s):
Mohamad A Hussein, MD, Principal Investigator, Affiliation: The Cleveland Clinic
John A Lust, MD, PhD, Study Chair, Affiliation: Mayo Clinic

The purpose of this study is to evaluate the efficacy of Enbrel in patients with primary systemic Amyloidosis.

Study design: Treatment, Non-Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Primary outcome: clinical efficacy

Secondary outcome:

Duration of response and time to progression

Evaluate overall survival

Identify prognostic factors

Evaluate qualitative and quantitative toxicities of Enbrel

Detailed description: The primary goal of this study is to evaluate the efficacy of Enbrel in patients with primary systemic amyloidosis using a one-stage, phase II study design with an interim analysis. This study will also assess survival and progression times, symptom relief, and toxicity associated with Enbrel in primary systemic amyloidosis patients. Two groups of patients with very different risk profiles can be identified with respect to this disease. Patients with symptomatic cardiac disease and/or at least two involved organs ar at high risk and historically have a median survival less than six months. Patients without these conditions have a significantly better prognosis. Both subgroups will be studied in the present study, and essentially two phase-II clinical trials, one for each subgroup, will be run in parallel.

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: >=18 years of age. Laboratory values obtained <=14 days prior to registration. No limitation on the cardiac ejection fraction Bilirubin <3 mg/dL Absolute neutrophil count >=500/microliters Histochemical diagnosis of amyloidosis as based on detection by polarizing microscopy of green bi-refringent material in Congo red-stained tissue specimens or characteristic electron microscopy appearance. Demonstrable M-protein in the serum/urine or clonal population of plasma cells in the bone marrow or immunohistochemical stain with anti-light chain anti-sera of amyloid fibrils. ECOG performance status 0, 1, 2, or 3. Symptomatic organ involvement with amyloid to justify therapy. This could include liver involvement, cardiac involvement, renal involvement, peripheral neuropathy, or soft tissue involvement. Must have more than purpura or carpal tunnel syndrome. Previously treated or untreated. No limit to prior therapy provided there is adequate residual organ function. Ability to provide informed consent. Ability to self-inject medication or have a caregiver who can administer the drug. Exclusion Criteria: Amyloid-specific syndrome, such as, carpal tunnel syndrome or skin purpura as only evidence of disease. The finding of vascular amyloid only in a bone marrow biopsy specimen or in a plasmacytoma is not indicative of systemic amyloidosis. Presence of non-AL amyloidosis. Melphalan or other alkylating agents, high-dose dexamethasone or alpha interferon <=4 weeks prior to registration. Concurrent use of corticosteroids, but patients may be on chronic steroids if they are being given for disorders other than amyloid, i. e., adrenal insufficiency, rheumatoid arthritis, etc. Any of the following: Pregnant women Nursing women Men or women of childbearing potential who are unwilling to employ adequate contraception (condoms, diaphragm, birth control pills, injections, intrauterine device [IUD], surgical sterilization, abstinence, etc.) Uncontrolled infection. Clinically overt multiple myeloma (monoclonal BMPC >30%), and at least one of the following: Bone lesions Hypercalcemia Active malignancy with the exception of adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years.

Starting date: February 2001
Ending date: August 2005
Last updated: September 21, 2005