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Comparison of a Water-soluble Topical Antimicrobial to Silver Sulfadiazine in Partial Thickness Burns

Information source: University of Virginia
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Burn

Intervention: water-soluble therapy (Drug); silver sulfadiazine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: University of Virginia

Official(s) and/or principal investigator(s):
Jonathan Black, MD, Principal Investigator, Affiliation: University of Virginia


Partial thickness burns are a common, painful injury requiring a great deal of resources in their care. Silver sulfadizine is a commonly-used topical antimicrobial, but is difficult to remove due to its lipid base. We are comparing a water-based topical antimicrobial therapy to silver sulfadiazine and hypothesize that the water-based therapy is superior in terms of pain control and resources required to deliver care.

Clinical Details

Official title: A Prospective Randomized Trial Comparing Silver Sulfadiazine Cream to a Water-Soluble Poly-Antimicrobial Gel in Partial Thickness Burn Wounds

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Pain level

Secondary outcome: time to perform dressing changes


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- adult inpatients with partial thickness burns

Exclusion Criteria:

- superficial or full thickness burns, facial burns, intubated or sedated, pediatric

Locations and Contacts

University of Virginia Health System, Charlottesville, Virginia 22908, United States
Additional Information

Starting date: April 2011
Last updated: August 20, 2013

Page last updated: August 23, 2015

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