Aizthromycin or Clarithromycin in H-pylori Eradication Regimen

Condition(s) targeted: Peptic Ulcer; Dyspepsia; H-pylori

Intervention: azithromycin (Drug); clarithmycin (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Shahid Sadoughi University of Medical Sciences and Health Services

The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Official title: Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: H-pylori cinfirmation

Secondary outcome:

h-pylori eradication confirmation

side effect of study srugs

Detailed description: Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries. There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy

Exclusion Criteria:

- patients who got H-pylori eradication treatment previously

- patients who used study drugs during 3months before study

Behnam Baghianimoghadam, Yazd 8916863411, Iran, Islamic Republic of

Starting date: March 2011
Last updated: August 15, 2012