Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections
Information source: Fraser Health
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Blood Stream Infections; Skin Diseases, Infectious
Intervention: Polysporin Triple Therapy ointment (Drug); Petroleum Jelly (Other)
Phase: N/A
Status: Withdrawn
Sponsored by: Fraser Health Official(s) and/or principal investigator(s): Steven Reynolds, MD, Principal Investigator, Affiliation: Fraser Health Authority
Summary
The purpose of the study is to determine if the overall central venous catheter related
infection rate can be reduced by the application of Polysporin Triple Therapy ointment to
the insertion site.
Clinical Details
Official title: Pilot Study: Topical Antibiotics for Prevention of ICU Central Line Infections
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: Overall number of line related infections (local and blood borne)
Secondary outcome: Length of ICU stayLength of hospital stay Prevalence of methicillin-resistant Staphylococcus Aureus (MRSA)
Detailed description:
Previous studies in the dialysis population have found a reduction in local and system
central venous catheter related infections with the application of topical antibiotics to
the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy
ointment. We intend to determine if this preparation can reduce overall line infection rates
in the ICU environment through its application at the time of line insertion and twice more
the following week.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- all patients admitted to the ICU requiring a central venous catheter
Exclusion Criteria:
- previous line infection during same ICU stay
- CVC for hemodialysis
Locations and Contacts
Royal Columbian Hospital, New Westminster, British Columbia V3L 1A1, Canada
Additional Information
Related publications: Lok CE, Stanley KE, Hux JE, Richardson R, Tobe SW, Conly J. Hemodialysis infection prevention with polysporin ointment. J Am Soc Nephrol. 2003 Jan;14(1):169-79. James MT, Conley J, Tonelli M, Manns BJ, MacRae J, Hemmelgarn BR; Alberta Kidney Disease Network. Meta-analysis: antibiotics for prophylaxis against hemodialysis catheter-related infections. Ann Intern Med. 2008 Apr 15;148(8):596-605.
Starting date: November 2009
Last updated: May 28, 2015
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