Beta-Blocker Heart Attack Trial (BHAT)
Information source: National Heart, Lung, and Blood Institute (NHLBI)
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Arrhythmia; Cardiovascular Diseases; Coronary Disease; Death, Sudden, Cardiac; Heart Diseases; Myocardial Infarction; Myocardial Ischemia; Ventricular Fibrillation
Intervention: propranolol (Drug)
Phase: Phase 3
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Official(s) and/or principal investigator(s):
Allan Barker, Affiliation: Salt Lake Clinic Research Foundation
Nemat Borhani, Affiliation: University of California, Davis
Gerald Breneman, Affiliation: Henry Ford Hospital
Frank Canosa, Affiliation: Miami Heart Institute
Robert Capone, Affiliation: Rhode Island Hospital
Richard Crow, Affiliation: University of Minnesota
Richard Crow, Affiliation: University of Minnesota
Alan Forker (participated until Feb, Affiliation: University of Nebraska
Peter Gazes, Affiliation: University of South Carolina
John Gregory, Affiliation: Atlantic Health System
John Grover, Affiliation: Kaiser Foundation Research Institute
Olga Haring, Affiliation: Northwestern University
Julian Haywood, Affiliation: University of Southern California
William Holmes, Affiliation: Lankenau Hospital
Frank Ibbott, Affiliation: Bio-Science Laboratories
Robert Kohn, Affiliation: State University of New York
Robert Kramer, Affiliation: Long Island Jewish-Hillside Medical Center
Peter Kuo, Affiliation: New Jersey College of Medicine and Dentistry-Rutgers
Charles Laubach, Affiliation: Geisinger Medical Center
Edgar Lichstein, Affiliation: Maimonides Medical Center
Louis Matthews, Affiliation: Dartmouth-Hitchcock Medical Center
Gordon Maurice, Affiliation: Providence Medical Center
J. McNamara, Affiliation: Pacific Health Research Institute
E. Michau, Affiliation: Veterans Administration Hospital
Richard Miller, Affiliation: Baylor College of Medicine
Joel Morganroth, Affiliation: Anthropometrics Heart Clinic
Robert Peters, Affiliation: University of California
Thaddeus Prout, Affiliation: Greater Baltimore Medical Center
Phillip Ranheim, Affiliation: MOUNT SINAI HOSPITAL
David Richardson, Affiliation: Medical College of Virginia
Robert Schlant, Affiliation: Emory University
James Schoenberger, Affiliation: Rush-Presbyterian-St.Luke's Hospital
Pierre Theroux, Affiliation: Montreal Heart Institute
Pantel Vokonas, Affiliation: Boston University
James Walsh, Affiliation: Veterans Administration Hospital
Gary Wilner, Affiliation: Evanston Northwestern Healthcare
Paul Yu, Affiliation: University of Rochester School of Medicine and Dentistry
To determine whether the regular administration of the beta-blocker drug propranolol to
people who had had at least one documented myocardial infarction would result in a
significant reduction of mortality from all causes over the follow-up period. Eligible
volunteer patients were recruited to participate in a double-blind clinical trial within 21
days after the onset of the acute event. One-half of the patients were randomly assigned to
a beta-blocking drug (propranolol) and one-half to a placebo. The trial also evaluated the
effect of propranolol on incidences of coronary heart disease mortality, sudden cardiac
death, and nonfatal myocardial infarction plus coronary heart disease mortality in persons
with documented previous myocardial infarction.
Study design: Prevention, Randomized, Double-Blind, Placebo Control
Survivors of a documented myocardial infarction are recognized as having a high risk of dying
relative to the general population. Serious arrhythmias, occurring with or without evidence
of new infarction, are a common cause of death in this population. Theoretically, an agent
which (1) can block the sympathetic nervous activity thought to be involved in precipitating
sudden death and (2) has non-neurogenic antiarrhythmic properties would be of value to people
with coronary heart disease. Propranolol, like other beta- blocking agents, has these as
well as other properties and therefore might be expected to prevent or retard complications
of coronary heart disease such as serious arrhythmias. This would be reflected in a decrease
in mortality due to coronary heart disease.
A workshop on chronic antiarrhythmic therapy reviewed contemporary experimental data and
clinical practice and recommended that a clinical trial be undertaken to clearly show the
effects of beta-blocking drugs on mortality. Subsequently, such a trial was approved by the
Clinical Applications and Prevention Advisory Committee, by the Cardiology Advisory
Committee, and by the National Heart, Lung, and Blood Advisory Council.
The study protocol was reviewed in February 1978 and recommended for approval by the
policy-data monitoring board and ad hoc members. The protocol was approved by the Director
of NHLBI in March 1978. Recruitment started on June 19, 1978, and ended in October 1980. A
total of 3,837 patients were randomized. Units which participated in the trial included 32
clinical centers, an EKG center, a central laboratory, a coordinating center, a 1-hour
ambulatory ECG center, a 24-hour ambulatory EKG center, and an EKG tape quality control
A randomized, double-blind design with single experimental and control groups. Patients were
recruited while in the hospital for an acute myocardial infarction and were enrolled in the
study before discharge. Eligible patients fulfilled the study definition of an acute
myocardial infarction. The diagnosis was based either on electrocardiographic records
showing evolving QRS segment changes or on ST segment and T wave changes together with enzyme
changes and appropriate clinical history. One-half of the patients were placed on therapy
using a beta-blocking drug (propranolol). The other half received a placebo. The prescribed
maintenance dosage of propranolol was either l80 or 240 mgs/day, depending upon serum drug
levels. Intervention duration averaged 25 months.
Minimum age: 30 Years.
Maximum age: 69 Years.
Men and women, ages 30 to 69. Documented myocardial infarction.
Locations and Contacts
Beta-Blocker Heart Attack Trial Study Group: Beta-Blocker Heart Attack Trial Study Protocol. DHHS Pub. No. (NIH)81-2209, 1980.
[No authors listed] The beta-blocker heart attack trial. beta-Blocker Heart Attack Study Group. JAMA. 1981 Nov 6;246(18):2073-4. No abstract available.
Howard JM, DeMets D. How informed is informed consent? The BHAT experience. Control Clin Trials. 1981 Dec;2(4):287-303.
[No authors listed] Beta Blocker Heart Attack Trial: design features. Control Clin Trials. 1981 Dec;2(4):275-85.
[No authors listed] A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA. 1982 Mar 26;247(12):1707-14.
Furberg C. The beta-blocker heart attack trial. Br J Clin Pharmacol. 1982;14 Suppl 1:3S-5S. No abstract available.
Furberg CD, Byington RP. What do subgroup analyses reveal about differential response to beta-blocker therapy? The Beta-Blocker Heart Attack Trial experience. Circulation. 1983 Jun;67(6 Pt 2):I98-101.
[No authors listed] A randomized trial of propranolol in patients with acute myocardial infarction. II. Morbidity results. JAMA. 1983 Nov 25;250(20):2814-9.
Goldstein S. The Beta-Blocker Heart Attack Trial in perspective. Cardiology. 1983;70(5):255-62.
Rouleau JL, Chatterjee K, Ports TA, Doyle MB, Hiramatsu B, Parmley WW. Mechanism of relief of pacing induced angina with oral verapamil: reduced oxygen demand. Circulation. 1983 Jan;67(1):94-100.
Shulman RS, Herbert PN, Capone RJ, McClure D, Hawkins CM, Henderson LO, Saritelli A, Campbell J. Effects of propranolol on blood lipids and lipoproteins in myocardial infarction. Circulation. 1983 Jun;67(6 Pt 2):I19-21.
Lichstein E, Morganroth J, Harrist R, Hubble E. Effect of propranolol on ventricular arrhythmia. The beta-blocker heart attack trial experience. Circulation. 1983 Jun;67(6 Pt 2):I5-10.
Goldstein S. Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial. Circulation. 1983 Jun;67(6 Pt 2):I53-7.
Byington RP. Beta-blocker heart attack trial: design, methods, and baseline results. Beta-blocker heart attack trial research group. Control Clin Trials. 1984 Dec;5(4):382-437.
Haywood LJ. Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria: the experience with the Beta Blocker Heart Attack Trial. Am Heart J. 1984 Sep;108(3 Pt 2):787-93.
Furberg CD, Hawkins CM, Lichstein E. Effect of propranolol in postinfarction patients with mechanical or electrical complications. Circulation. 1984 Apr;69(4):761-5.
DeMets DL, Hardy R, Friedman LM, Lan KK. Statistical aspects of early termination in the beta-blocker heart attack trial. Control Clin Trials. 1984 Dec;5(4):362-72.
Byington RP, Curb JD, Mattson ME. Assessment of double-blindness at the conclusion of the beta-Blocker Heart Attack Trial. JAMA. 1985 Mar 22-29;253(12):1733-6.
Byington R, Goldstein S. Association of digitalis therapy with mortality in survivors of acute myocardial infarction: observations in the Beta-Blocker Heart Attack Trial. J Am Coll Cardiol. 1985 Nov;6(5):976-82.
Morganroth J, Lichstein E, Byington R. Beta-Blocker Heart Attack Trial: impact of propranolol therapy on ventricular arrhythmias. Prev Med. 1985 May;14(3):346-57.
Bell RL, Curb JD, Friedman LM, McIntyre KM, Payton-Ross C. Enhancement of visit adherence in the national beta-blocker heart attack trial. Control Clin Trials. 1985 Jun;6(2):89-101.
Bell RL, Curb JD, Friedman LM, Payne GH. Termination of clinical trials: the beta-blocker heart attack trial and the hypertension detection and follow-up program experience. Control Clin Trials. 1985 Jun;6(2):102-11.
Walle T, Byington RP, Furberg CD, McIntyre KM, Vokonas PS. Biologic determinants of propranolol disposition: results from 1308 patients in the Beta-Blocker Heart Attack Trial. Clin Pharmacol Ther. 1985 Nov;38(5):509-18.
Friedman LM, Byington RP, Capone RJ, Furberg CD, Goldstein S, Lichstein E. Effect of propranolol in patients with myocardial infarction and ventricular arrhythmia. J Am Coll Cardiol. 1986 Jan;7(1):1-8.
Goldstein S, Byington R. The Beta Blocker Heart Attack Trial: recruitment experience. Control Clin Trials. 1987 Dec;8(4 Suppl):79S-85S.
Furberg CD, Friedman LM, MacMahon SW: Women as Participants in Trials of the Primary and Secondary Prevention of Cardiovascular Disease: Part II. Secondary Prevention: The Beta-Blocker Heart Attack Trial and the Aspirin Myocardial Infarction Study, in: Coronary Heart Disease in Women. Ed Eaker, B Packard, NK Wenger, TB Clarkson, HA Tyroler (Eds). New York, Haymarket Doyma, pp 241-246, 1987.
Kostis JB, Byington R, Friedman LM, Goldstein S, Furberg C. Prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction. J Am Coll Cardiol. 1987 Aug;10(2):231-42.
Peters RW, Byington R, Arensberg D, Friedman LM, Romhilt DW, Barker A, Laubach C, Wilner GW, Goldstein S. Mortality in the beta blocker heart attack trial: circumstances surrounding death. J Chronic Dis. 1987;40(1):75-82.
Davis BR, Furberg CD, Williams CB. Survival analysis of adverse effects data in the Beta-Blocker Heart Attack Trial. Clin Pharmacol Ther. 1987 Jun;41(6):611-5.
Davis BR, Friedman LM, Lichstein E. Are 24 hours of ambulatory ECG monitoring necessary for a patient after infarction? Am Heart J. 1988 Jan;115(1 Pt 1):83-91.
Peters RW, Muller JE, Goldstein S, Byington R, Friedman LM. Propranolol and the morning increase in the frequency of sudden cardiac death (BHAT Study). Am J Cardiol. 1989 Jun 15;63(20):1518-20. No abstract available.
Peters RW, Byington RP, Barker A, Yusuf S. Prognostic value of prolonged ventricular repolarization following myocardial infarction: the BHAT experience. The BHAT Study Group. J Clin Epidemiol. 1990;43(2):167-72.
Byington RP, Worthy J, Craven T, Furberg CD. Propranolol-induced lipid changes and their prognostic significance after a myocardial infarction: the Beta-Blocker Heart Attack Trial experience. Am J Cardiol. 1990 Jun 1;65(20):1287-91.
Gheorghiade M, Schultz L, Tilley B, Kao W, Goldstein S. Effects of propranolol in non-Q-wave acute myocardial infarction in the beta blocker heart attack trial. Am J Cardiol. 1990 Jul 15;66(2):129-33.
Peters RW. Propranolol and the morning increase in sudden cardiac death: (the beta-blocker heart attack trial experience). Am J Cardiol. 1990 Nov 6;66(16):57G-59G.
Gheorghiade M, Schultz L, Tilley B, Kao W, Goldstein S. Natural history of the first non-Q wave myocardial infarction in the placebo arm of the Beta-Blocker Heart Attack Trial. Am Heart J. 1991 Dec;122(6):1548-53.
Gheorghiade M, Shivkumar K, Schultz L, Jafri S, Tilley B, Goldstein S. Prognostic significance of electrocardiographic persistent ST depression in patients with their first myocardial infarction in the placebo arm of the Beta-Blocker Heart Attack Trial. Am Heart J. 1993 Aug;126(2):271-8.
Friedman LM, Byington RP. Assessment of angina pectoris after myocardial infarction: comparison of "Rose Questionnaire" with physician judgment in the Beta-Blocker Heart Attack Trial. Am J Epidemiol. 1985 Apr;121(4):555-62.
Starting date: September 1977
Ending date: October 1981
Last updated: June 23, 2005