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Phenylephrine Versus Norepinephrine in Ophthalmic Surgery

Information source: University Medical Center Groningen
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bloodpressure

Intervention: phenylephrine (Drug); norepinephrine (Drug)

Phase: N/A

Status: Completed

Sponsored by: University Medical Center Groningen

Official(s) and/or principal investigator(s):
Alain Kalmar, Dr, Principal Investigator, Affiliation: Anesthesiology

Summary

In ophthalmic surgery the specific anaesthesiological challenges necessitate the administration of a combination of relatively high doses of hypnotics and analgetics. In order to preserve adequate organ perfusion, there is often a need to administer pharmacological agents for haemodynamic support. Depending on the experience of the anaesthetist a continuous infusion of phenylephrine or norepinephrine is used. It is currently not known which of these agents has the most favorable haemodynamical profile. Haemodynamic parameters (continuous blood pressure, cardiac index, stroke volume and systemic resistance), peripheral tissue oxygenation and cerebral tissue oxygenation will be monitored noninvasively using the Nexfin® , Inspectra®, and Foresight® and O2C® monitoring devices.

Clinical Details

Official title: Comparison of the Effects of Phenylephrine and Norepinephrine on Hemodynamics and Tissue Oxygenation in Patients Undergoing Ophthalmic Surgery

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Primary outcome: the haemodynamical effects of norepinephrine and phenylephrine during ophthalmic surgery

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: Patients requiring general anaesthesia for ophthalmic surgery.

- Age > 18 years and older

- Diabetes or cardiovascular disease or age >55 years

Exclusion Criteria:

- Patient refusal

- Patient < 18 years

Locations and Contacts

University Medical Center Groningen, Groningen 9713gz, Netherlands
Additional Information

Starting date: January 2012
Last updated: April 4, 2014

Page last updated: August 23, 2015

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