MgSO4 Combined With Rocuronium Priming
Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Muscle Relaxation
Intervention: magnesium sulfate (Drug); priming (Drug); magnesium sulfate and priming (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Seoul National University Bundang Hospital Official(s) and/or principal investigator(s):
Sanghwan Do, M.D., PH.D., Study Chair, Affiliation: Seoul National University Bundang Hospital
Overall contact:
Mihyun Kim, MD, Phone: 82-31-787-2034, Email: snmd56@yahoo.com
Summary
Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on
muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the
rocuronium-priming.
Clinical Details
Official title: MgSO4 Combined With Rocuronium Priming
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: time from injection of induction dose of rocuronium until 95% depression of TOF
Secondary outcome: rocuronium durationintubating condition
Detailed description:
Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4
combined with priming is efficient in accelerating muscle relaxation, it would be an
interesting alternative to rapid-sequence intubation.
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients of ASA Ⅰ-Ⅱ
- aged 18~65
- scheduled to undergo elective surgery under general anesthesia
Exclusion Criteria:
- risk of pulmonary aspiration
- anticipated airway difficulty
- reactive airway disease
- allergic to study drugs
- neuromuscular / cardiovascular/ renal/ hepatic disease
- atrioventricular conduction disturbance
- BMI < 18. 5 or > 24. 9
- chronic treatment with calcium channel blocker
- medications which affect muscle relaxation
Locations and Contacts
Mihyun Kim, MD, Phone: 82-31-787-2034, Email: snmd56@yahoo.com
Seoul national university Bundang hospital, Seongnam, Kyoung-ki-do 463-707, Korea, Republic of; Recruiting
Additional Information
Starting date: May 2011
Last updated: January 6, 2012
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