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Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hyperprolactinoma

Intervention: Curcumin (Drug)

Phase: Phase 1

Status: Recruiting

Sponsored by: Mashhad University of Medical Sciences

Overall contact:
haleh rokni, proffessore assisstant, Phone: 00981082976, Email: roknih@mums.ac.ir


Prolactinoma is the most prevalent anterior hypophysis tumor. The principal treatment for this disorder is Dopamine agonist drugs including bromocriptin and Cabergoline. However, 50% of Bromocriptin treated and 17% of Cabergoline treated patients are resistant to these drugs. Curcumin is the main derivative of turmeric ,an old spice which is used frequently in Indian and Iranian cuisine. It has been proved that curcumin can reduce mammotrope cells proliferation and also intracellular hormone production. The purpose of this study is to evaluate the effect of turmeric on prolactinoma patients.

Clinical Details

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: serum prolactin level

Secondary outcome: change in LH,FSH and estradiol from baseline


Minimum age: 20 Years. Maximum age: 45 Years. Gender(s): Female.


Inclusion Criteria:

- hyperprolactinemia

- microprolactinoma

Exclusion Criteria:

- pregnancy

- macroadenoma

- neurologic signs due to tumor

Locations and Contacts

haleh rokni, proffessore assisstant, Phone: 00981082976, Email: roknih@mums.ac.ir

Mashad University of Medical Sciences, Mashad, Khorasan Razavi, Iran, Islamic Republic of; Recruiting
haleh rokni, Phone: 00985118012976, Email: roknih@mums.ac.ir
Additional Information

Starting date: July 2011
Last updated: October 29, 2011

Page last updated: August 23, 2015

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