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Methylprednisolone Addition in IVF Treatment of Infertile Couples

Information source: Universitair Ziekenhuis Brussel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: In Vitro Fertilization

Intervention: In vitro fertilization treatment for infertility (Other)

Phase: Phase 4

Status: Recruiting

Sponsored by: Universitair Ziekenhuis Brussel

Official(s) and/or principal investigator(s):
Basil Tarlatzis, Professor, Study Chair, Affiliation: BioGenesis

Overall contact:
Evangelos Papanikolaou, MD, Phone: 0030 2310 424284, Email: drvagpapanikolaou@yahoo.gr


Hypothesis to be tested is whether follicular addition of Methylprednisolone can efficiently control late follicular progesterone rise during IVF treatment

Clinical Details

Official title: Methylprednisolone vs. Placebo to Control Late Follicular Progesterone Elevation in GnRH-Antagonist IVF Cycles

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: Progesterone rise above 1.5ng.ml on the day of HCG

Secondary outcome: Clinical pregnancy rate

Detailed description: The aim is to investigate any potential advantages of adding cortisone supplementation from the follicular phase onwards with regard to premature luteinization, oocyte quality, embryo quality and pregnancy outcome.


Minimum age: 21 Years. Maximum age: 36 Years. Gender(s): Female.


Inclusion Criteria:

- less than 36, more than 10 antral follicles, FSH<12

Exclusion Criteria:

- endometriosis stage III&IV,

Locations and Contacts

Evangelos Papanikolaou, MD, Phone: 0030 2310 424284, Email: drvagpapanikolaou@yahoo.gr

Biogenesis, Thessaloniki, Pylaia 55536, Greece; Recruiting
Evangelos Papanikolaou, MD,PhD, Phone: 0030 2310 989160, Email: drvagpapanikolaou@yahoo.gr
Additional Information

web page of investigator centre

Related publications:

Bider D, Menashe Y, Goldenberg M, Dulitzky M, Lifshitz A, Dor J. Dexamethasone as an adjuvant therapy for anovulatory, normoandrogenic patients during ovulation induction with exogenous gonadotropins. J Assist Reprod Genet. 1996 Sep;13(8):613-6.

Starting date: January 2009
Last updated: October 13, 2010

Page last updated: August 23, 2015

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