DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Slow-wave Sleep Deprivation in Depression

Information source: University of Wisconsin, Madison
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Major Depressive Disorder

Intervention: Slow-wave deprivation (Device)

Phase: N/A

Status: Completed

Sponsored by: University of Wisconsin, Madison

Official(s) and/or principal investigator(s):
Ruth M Benca, M.D., Ph.D, Principal Investigator, Affiliation: University of Wisconsin, Madison

Summary

Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be explained by abnormal slow wave homeostasis. This study will test the prediction that selectively reducing slow waves during sleep (slow wave deprivation; SWD), without disrupting total sleep time, will yield an antidepressant effect.

Clinical Details

Official title: Slow-wave Sleep Deprivation as a Possible Treatment for Major Depressive Disorder

Study design: Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Primary outcome: Hamilton Depression Scale

Secondary outcome: Inventory of Depressive Symptomology

Detailed description: see above

Eligibility

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Among the inclusion criteria will be:

- age range 18-35 years

- right handedness

- major depressive disorder according to DSM-IV (Diagnostic and Statical

Manual-Revision 4) criteria (as determined by the Structured Clinical Interview for Diagnostic and Statical Manual-Revision 4), with Hamilton Rating Scale for *Depression scores of at least 18 on the first 17 items

- no psychotropic medications for at least 4 weeks

- no joint and muscular di

- normal hearing

- regular bedtimes and sleep duration, no time zone shifts in the last three

weeks. Exclusion Criteria:

- Diabetes requiring insulin treatment

- A serious heart disorder or subjects who have had a heart attack within the last 3

months

- A diagnosis of cancer in the past 3 years and/or has active neoplastic disease

- Clinically significant abnormalities on pre-study physical exam or physician

evaluation

- Subjects who meet DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria for

alcohol/drug abuse problems within the last six months or are currently using illegal drugs.

- Female subjects of child-bearing potential who are pregnant or planning to become

pregnant.

- Women of child-bearing must be practicing a medically acceptable form of birth

control.

- Women of childbearing potential will be questioned about pregnancy status and form of

birth control to be used at each visit.

- Women who are unsure of their pregnancy status will be given a urine pregnancy test.

- Subjects taking investigational medications

- Subjects currently undergoing electroconvulsive therapy (ECT) or therapeutic

transcranial magnetic stimulation (TMS).

- Subjects who regularly perform night or late evening shift work (e. g. - "second" or

"third" shifts) or have had travel with time zone shifts >3h in the last 3 weeks

Locations and Contacts

Wisconsin Center for Sleep Medicine and Research, Madison, Wisconsin 53719, United States
Additional Information

Starting date: June 2009
Last updated: May 20, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017