Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy
Information source: Shiraz University of Medical Sciences
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Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Contrast Induced Nephropathy
Intervention: sodium bicarbonate (Drug); Acetazolamide (Drug); normal salin (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Shiraz University of Medical Sciences Official(s) and/or principal investigator(s):
Maryam Pakfetrat, MD, Study Chair, Affiliation: Shiraz nephro-urology research center
Summary
The purpose of this study is whether Acetazolamide is effective in prevention of contrast
nephropathy
Clinical Details
Official title: Effect of Acetazolamide in Prevention of Contrast Nephropathy
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Primary outcome: Increased base line creatinine at least 25%
Detailed description:
Contrast induced nephropathy is one of common causes of acute renal failure many preventive
protocol existed . 240 patient that underwent coronary angiography randomly divided in
three groups. Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal
salin respectively. We compare prevalence of contrast nephropathy in each group.
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patient that underwent coronary angiography
Exclusion Criteria:
- serum Cr. more than 3 mg/dl
- electrolyte and acid-base imbalance
- pulmonary edema
- allergy to Acetazolamide
Locations and Contacts
Fars Heart Foundation , Kowsar hospital, Shiraz, Iran, Islamic Republic of
Additional Information
Starting date: September 2007
Last updated: March 4, 2008
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