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Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Information source: Shiraz University of Medical Sciences
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Contrast Induced Nephropathy

Intervention: sodium bicarbonate (Drug); Acetazolamide (Drug); normal salin (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Shiraz University of Medical Sciences

Official(s) and/or principal investigator(s):
Maryam Pakfetrat, MD, Study Chair, Affiliation: Shiraz nephro-urology research center

Summary

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Clinical Details

Official title: Effect of Acetazolamide in Prevention of Contrast Nephropathy

Study design: Prevention, Randomized, Double Blind (Subject, Investigator), Active Control, Parallel Assignment

Primary outcome: Increased base line creatinine at least 25%

Detailed description: Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups. Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively. We compare prevalence of contrast nephropathy in each group.

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patient that underwent coronary angiography

Exclusion Criteria:

- serum Cr. more than 3 mg/dl

- electrolyte and acid-base imbalance

- pulmonary edema

- allergy to Acetazolamide

Locations and Contacts

Fars Heart Foundation , Kowsar hospital, Shiraz, Iran, Islamic Republic of
Additional Information

Starting date: September 2007
Ending date: February 2008
Last updated: March 4, 2008

Page last updated: June 20, 2008

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