Hyzaar Asia HEAALTH
Information source: Merck
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertension
Intervention: MK0954A [hydrochlorothiazide (+) losartan potassium]/Duration of Treatment: 13 Weeks (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Merck Official(s) and/or principal investigator(s):
Medical Monitor, Study Director, Affiliation: Merck
Summary
The objective of the study is to estimate the percentage of patients who reach blood pressure
goal after 8 weeks of treatment with losartan/HCTZ combination.
Clinical Details
Official title: An Open Label Study to Assess the Efficacy of Losartan/HCTZ Combination Therapy in Patients With Essential Hypertension Who Were Inadequately Controlled on Current Antihypertensive Monotherapy
Study design: Treatment, Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Primary outcome: Percentage of patients reaching a blood pressure goal (diastolic <90mm Hg for non-diabetics; <80mm Hg for diabetics) after 8 weeks of treatment
Secondary outcome: Safety and tolerability
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patient is male or female and ≥ 18 years of age.
- Patients with essential hypertension previously treated with antihypertensive
medications for at least 4 weeks but did not reach the blood pressure goal
Exclusion Criteria:
- History of any condition, therapy, lab abnormality or other circumstance that might
confound the results of the study, or interfere with the patient’s participation for
the full duration of the study, such that it is not in the best interest of the
patient/subject to participate.
- Pregnant or breastfeeding, or expecting to conceive within the projected duration of
the study
- Previous history of severe essential hypertension
- History of stroke or myocardial infarction (heart attack)
- Evidence of renal or liver disease
- Uncontrolled diabetes mellitus
- Any known bleeding disorder
- Known sensitivity or intolerance to the study medication (losartan or
hydrochlorothiazide)
- Other antihypertensive medications or medications that may affect blood pressure
Locations and Contacts
Additional Information
Starting date: June 2006
Ending date: April 2007
Last updated: May 3, 2007
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