Effects of Pretreatment With Ibuprofen in Post-Electroconvulsive Therapy (ECT) Headache

Condition(s) targeted: Mental Disorders

Intervention: Ibuprofen (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Norwegian University of Science and Technology

Official(s) and/or principal investigator(s):
Olav Morten Linaker, MD PhD, Principal Investigator, Affiliation: Norwegian University of Science and Technology

Overall contact:
Lindy Jarosch-von Schweder, MD, Phone: 47 73864533, Email: lindy.jarosch@ntnu.no

The purpose of the study is to determine wether ibuprofen reduce post-ECT headache or reduce its severity.

Official title: Effects of Pretreatment With Ibuprofen in Post- ECT Headache

Study design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study

Primary outcome:

Score on depression rating scale prior to and after ECT treatment

score on headache prior to and after ECT treatment

Secondary outcome: ECT parameters

Detailed description: The aim of the study is to compare the severity of headache between patients who are receiving ibuprofen prior to ECT treatment with patients receiving placebo prior to ECT treatment.

Patients will be randomly assigned to receive either 600 mg ibuprofen 90 min prior to treatment or placebo orally, blinded to patient, physician and treatment team.

Patients will be asked about their headache with a visual analogue scale (VAS) 2 hours prior to and within 2 hours after treatment, 2-month, 6- month and 1 year follow-up [5].

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients receiving ECT

Exclusion Criteria:

- Pregnancy, contraindications to ibuprofen

Lindy Jarosch-von Schweder, MD, Phone: 47 73864533, Email: lindy.jarosch@ntnu.no

Østmarka Psychiatric Department, St. OLavs Hospital, University Hospital of Trondheim, Trondheim, Norway

Starting date: August 2008
Ending date: June 2010
Last updated: April 18, 2008