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Immune Regulation in Multiple Sclerosis: MicroRNA and Antigen-Presenting Cells

Information source: Rutgers, The State University of New Jersey
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Multiple Sclerosis

Phase: N/A

Status: Completed

Sponsored by: Rutgers, The State University of New Jersey

Official(s) and/or principal investigator(s):
Konstantin Balashov, MD, PhD, Principal Investigator, Affiliation: Rutgers-RWJMS

Summary

MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and interferon-beta-treated patients with multiple sclerosis.

Clinical Details

Official title: Immune Regulation in Multiple Sclerosis: MicroRNA and Antigen-Presenting Cells

Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional

Primary outcome: Relative MicroRNA expression in B cells

Detailed description: MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and interferon-beta-treated patients with multiple sclerosis. The expression of microRNA will be analysed in cell subsets separated from peripheral blood mononuclear cells.

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- 18-60 year-old healthy subjects or patients with RRMS/CIS

Exclusion Criteria: 1. Any treatment with steroids in the last 30 days prior to the blood draw or any immunosuppressive or Disease-modifying treatment (DMT) other than Glatiramer Acetate in the last 90 days 2. Presence of other disorders that may be associated with immune-deficient or autoimmune process (e. g., HIV, lymphoma, lupus) or demyelinating disease other than MS (e. g., Lyme, B12 deficiency) 3. Pregnancy 4. Intermittent or unilateral constant assistance (cane, crutch, brace) required to walk about 100 meters with or without resting (Expanded Disability Status Scale (EDSS) score greater than 5. 5 )

Locations and Contacts

Rutgers-RWJMS, New Brunswick, New Jersey 08901, United States
Additional Information

Starting date: November 2011
Last updated: November 19, 2013

Page last updated: August 20, 2015

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