The purpose of this study is to evaluate the effects of Ceftazidime Avibactam plus
Metronidazole compared to Meropenem for treating hospitalized patients with complicated
intra-abdominal infections.
The proportion of patients with clinical cure in the microbiologically evaluable and extended microbiologically evaluable analysis setThe proportion of patients with clinical cure in the microbiological modified intent-to-treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The proportion of patients with clinical cure in the clinically evaluable analysis set.
The proportion of patients with a favorable per-patient microbiological response in the microbiological modified intent to treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The proportion of favorable per-pathogen microbiological response in the microbiological modified intent to treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
The favorable per-pathogen microbiologic response by minimum inhibitory concentration (MIC) categories in the microbiological modified intent to treat, microbiologically evaluable, and extended microbiologically evaluable analysis sets
Favorable per-patient clinical response & microbiological response for patients infected with ceftazidime-resistant pathogens in microbiological modified intent to treat, microbiologically evaluable & extended microbiologically evaluable analysis sets
Proportion of patients with favorable per-pathogen microbiological response for patients infected with ceftazidime-resistant pathogens in microbiological modified ITT, microbiologically evaluable and extended microbiologically evaluable analysis sets
The time to first defervescence in the clinically evaluable, microbiologically evaluable, and extended microbiologically evaluable analysis sets for patients who have fever at study entry
The safety and tolerability by incidence and severity of adverse events and serious adverse events, vital signs, clinical laboratory tests, ECGs and physical exams.
Pharmacokinetics: maximum concentration (Cmax), minimum concentration, area under the plasma concentration time curve at steady state, and terminal half-life
Minimum age: 18 Years.
Maximum age: 90 Years.
Gender(s): Both.
Research Site, Córdoba, Argentina
Research Site, Rosario, Argentina
Research Site, Ruse, Bulgaria
Research Site, Varna, Bulgaria
Research Site, Zagreb, Croatia
Research Site, Decin, Czech Republic
Research Site, Hradec Kralove, Czech Republic
Research Site, Jihlava, Czech Republic
Research Site, Olomouc, Czech Republic
Research Site, Praha 10, Czech Republic
Research Site, Praha 5, Czech Republic
Research Site, Teplice, Czech Republic
Research Site, Budapest, Hungary
Research Site, Székesfehérvár, Hungary
Research Site, Bangalore, India
Research Site, Pune, India
Research Site, Trivandrum, India
Research Site, Vadodara, India
Research Site, Hadera, Israel
Research Site, Haifa, Israel
Research Site, Riga, Latvia
Research Site, Alor Setar, Malaysia
Research Site, Durango, Mexico
Research Site, Guadalajara, Jalisco, Mexico
Research Site, Mexico City, Mexico
Research Site, Enschede, Netherlands
Research Site, s-Hertogenbosch, Netherlands
Research Site, Arequipa, Peru
Research Site, Cercardo de Lima, Peru
Research Site, Lima, Peru
Research Site, Trujillo, Peru
Research Site, Cluj-Napoca, Romania
Research Site, Iasi, Romania
Research Site, Kemerovo, Russian Federation
Research Site, Moscow, Russian Federation
Research Site, Saratov, Russian Federation
Research Site, Vsevolozhsk, Russian Federation
Research Site, Pretoria, South Africa
Research Site, Alcorcón, Spain
Research Site, Elche, Spain
Research Site, Sabadell(Barcelona), Spain
Research Site, Kaohsiung, Taiwan
Research Site, Taichung, Taiwan
Research Site, Tainan, Taiwan
Research Site, Taipei, Taiwan
Research Site, Bangkok, Thailand
Research Site, Khon Kaen, Thailand
Research Site, Phisanulok, Thailand
Research Site, Dnipropetrovsk, Ukraine
Research Site, Ivano-Frankivsk, Ukraine
Research Site, Kharkov, Ukraine
Research Site, Kyiv, Ukraine
Research Site, Zaporizhzhya, Ukraine
Research Site, Chula Vista, California, United States
Research Site, San Diego, California, United States
Research Site, St. Louis, Missouri, United States
Research Site, Somers Point, New Jersey, United States