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The Effect of Etomidate on Outcomes of Trauma Patients

Information source: Advocate Hospital System
Information obtained from ClinicalTrials.gov on October 04, 2010
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Trauma

Intervention: Etomidate (Drug); Midazolam (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Advocate Hospital System

Overall contact:
Karis Tekwani, MD, Phone: 708-684-3889, Email: karistekwani@gmail.com

Summary

Rationale: The drug etomidate causes increased mortality if used for continuous sedation in mechanically ventilated patients; however, etomidate continues to be widely used as a single-bolus induction agent for endotracheal intubation because of its favorable hemodynamic properties. Recent data have raised questions regarding the safety of using etomidate for even a single bolus in patients at risk of adrenal insufficiency, emphasizing the fact that single bolus doses of etomidate cause measurable adrenal suppression, and consequently may cause increases in vasopressor requirements and in hospital length of stay. Alternative FDA-approved induction agents, such as midazolam, may be safer than etomidate; however, no studies have formally compared these agents.

Research Hypothesis: The investigators hypothesize that in critically ill trauma patients presenting to the emergency department requiring rapid sequence intubation, the hospital length of stay for patients given etomidate will be greater than for patients given midazolam for induction.

Specific Aims: The specific aim is to determine the difference in hospital length of stay between trauma patients given etomidate and those given midazolam for induction during rapid sequence intubation in the emergency department. The investigators plan to compare the two groups in terms of hospital length of hospital stay, length of stay in the intensive care unit, and duration of intubation by performing a prospective, randomized, trial of critically ill trauma patients presenting to the emergency department requiring intubation. The investigators will also compare the mortality rates in these two groups while controlling for severity of illness and the use of steroids while hospitalized.

Significance: If the use of etomidate to induce anesthesia prior to intubation adversely affects the hospital length of stay of trauma patients, this length of stay might be reduced in such patients by using alternative agents for induction. Since etomidate is currently in widespread use as an induction agent, the results of this study could have significant implications for patient management.

Clinical Details

Official title: The Effect of Etomidate on Outcomes of Trauma Patients

Study design: Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Double-Blind

Primary outcome: Length of Stay

Eligibility

Minimum age: 14 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All critically ill trauma patients (defined as patients over the age of 14 years

requiring trauma team activation) who present to the ED in need of ventilatory support due to the severity of their illness and injuries.

Exclusion Criteria:

- Age less than 14, do-not-resuscitate status, or cardiopulmonary arrest prior to

arrival in the ED.

Locations and Contacts

Karis Tekwani, MD, Phone: 708-684-3889, Email: karistekwani@gmail.com

Advocate Christ Medical Center, Oak Lawn, Illinois 60453, United States
Additional Information


Last updated: July 13, 2009

Page last updated: October 04, 2010

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