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Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Information source: Shiraz University of Medical Sciences
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atrial Fibrillation

Intervention: Amiodarone + Propranolol (Drug); Amiodarone (Drug); Propranolol (Drug)

Phase: N/A

Status: Completed

Sponsored by: Shiraz University of Medical Sciences

Summary

Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG

Clinical Details

Official title: Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study

Study design: Prevention, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Safety/Efficacy Study

Primary outcome: incidence of atrial fibrillation post CABG

Secondary outcome: bradycardia, mortality, hypotension, morbidity

Detailed description: In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).

All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.

Eligibility

Minimum age: 45 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patient who are going to have elective CABG

- Signing informed consent

Exclusion Criteria:

- EF<35%

- Bradycardia<60 per min

- Hypotension< 100 mmhg

Locations and Contacts

Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital, shiraz, Fars 71345, Iran, Islamic Republic of
Additional Information

Starting date: March 2007
Ending date: February 2008
Last updated: April 4, 2008

Page last updated: June 20, 2008

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