Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft
Information source: Shiraz University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Atrial Fibrillation
Intervention: Amiodarone + Propranolol (Drug); Amiodarone (Drug); Propranolol (Drug)
Sponsored by: Shiraz University of Medical Sciences
Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently
B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of
propranolol and amiodarone separately and together to find a better prophylaxis for AF
Official title: Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: incidence of atrial fibrillation post CABG
Secondary outcome: bradycardia, mortality, hypotension, morbidity
In this double blind randomized study 240 consecutive patients underwent elective coronary
artery bypass grafting, being randomized prospectively into three groups, propranolol (p)
(n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).
All groups received their medications from 7 days preoperatively and continued their
medications for 5 days post CABG.
Minimum age: 45 Years.
Maximum age: 70 Years.
- Patient who are going to have elective CABG
- Signing informed consent
- Bradycardia<60 per min
- Hypotension< 100 mmhg
Locations and Contacts
Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital, Shiraz, Fars 71345, Iran, Islamic Republic of
Starting date: March 2007
Last updated: April 4, 2008