Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft
Information source: Shiraz University of Medical Sciences
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Atrial Fibrillation
Intervention: Amiodarone + Propranolol (Drug); Amiodarone (Drug); Propranolol (Drug)
Phase: N/A
Status: Completed
Sponsored by: Shiraz University of Medical Sciences
Summary
Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently
B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of
propranolol and amiodarone separately and together to find a better prophylaxis for AF
peri-CABG
Clinical Details
Official title: Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study
Study design: Prevention, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: incidence of atrial fibrillation post CABG
Secondary outcome: bradycardia, mortality, hypotension, morbidity
Detailed description:
In this double blind randomized study 240 consecutive patients underwent elective coronary
artery bypass grafting, being randomized prospectively into three groups, propranolol (p)
(n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).
All groups received their medications from 7 days preoperatively and continued their
medications for 5 days post CABG.
Eligibility
Minimum age: 45 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patient who are going to have elective CABG
- Signing informed consent
Exclusion Criteria:
- EF<35%
- Bradycardia<60 per min
- Hypotension< 100 mmhg
Locations and Contacts
Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital, shiraz, Fars 71345, Iran, Islamic Republic of
Additional Information
Starting date: March 2007
Ending date: February 2008
Last updated: April 4, 2008
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