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Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia

Information source: Sahlgrenska University Hospital, Sweden
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Blood Pressure; Hematocrit Change; Anesthesia

Intervention: Maintained blood pressure (Procedure); Norepinephrine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Sahlgrenska University Hospital, Sweden

Official(s) and/or principal investigator(s):
Andreas Nygren, MD PHD, Principal Investigator, Affiliation: Sweden: Sahlgrenska University hospital

Overall contact:
Tor Damén, MD, Phone: +46313427873, Email: tor.damen@vgregion.se

Summary

The arterial blood pressure affects the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the hematocrit. During induction of anesthesia blood pressure, hemoglobin level and hematocrit decreases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the decrease in hematocrit.

Clinical Details

Official title: Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: The magnitude and dynamics of the decrease in hematocrit during anesthesia induction

Secondary outcome: Reduced hematocrit decrease by vasopressor infusion maintained blood pressure

Detailed description: 24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Arterial blood gas will be analysed every ten minutes. Equal anesthesia in both groups will be monitored. No fluids will be infused. Noninvasive continuous hemoglobin measurement (SpHb) will be measured.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Elective coronary artery surgery patients

Exclusion Criteria:

- Age under 18 years

- untreated hypertension

- a reduced left ventricular systolic ejection fraction of 45 % or less

- diabetes mellitus

- former stroke and/or a known carotid artery stenosis.

Locations and Contacts

Tor Damén, MD, Phone: +46313427873, Email: tor.damen@vgregion.se

Sahlgrenska University Hospital, Gothenburg 41345, Sweden; Recruiting
Andreas Nygren, MD PHD, Phone: +46313427444, Email: andreas.nygren@aniv.gu.se
Additional Information

Starting date: February 2014
Last updated: April 4, 2015

Page last updated: August 23, 2015

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