This randomized, multicenter, double-blind, parallel group study will evaluate the impact of
methotrexate (MTX) discontinuation on the efficacy of subcutaneous RoActemra/Actemra
(tocilizumab) in patients with moderate to severe active rheumatoid arthritis who have an
inadequate response to current MTX therapy. Patients will be initiated on RoActemra/Actemra
162 mg weekly or every 2 weeks, remaining on a stable dose of MTX. At Week 24, patients
achieving a disease activity score (DAS28) =3. 2 will be randomized to either continue
receiving a stable dose of MTX or to switch to matching placebo until Week 52. In an MRI
substudy of patients in both treatment arms (MTX or placebo), MRI images of hands and wrists
will be obtained and analyzed.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Reference Study ID Number: ML28776 www.roche.com/about_roche/roche_worldwide.htm, Phone: 888-662-6728 (U.S. Only), Email: global.rochegenentechtrials@roche.com
Anniston, Alabama 36207, United States; Recruiting
Birmingham, Alabama 35294, United States; Recruiting
Huntsville, Alabama 35801, United States; Recruiting
Tuscaloosa, Alabama 35406, United States; Recruiting
Glendale, Arizona 85306, United States; Recruiting
Mesa, Arizona 85202, United States; Recruiting
Paradise Valley, Arizona 85253, United States; Recruiting
Phoenix, Arizona 85027, United States; Recruiting
Phoenix, Arizona 85037, United States; Recruiting
Scottsdale, Arizona 85258, United States; Recruiting
Tucson, Arizona 85712, United States; Not yet recruiting
Fort Smith, Arkansas 72903, United States; Recruiting
Hot Springs, Arkansas 71913, United States; Recruiting
Jonesboro, Arkansas 72401, United States; Recruiting
Little Rock, Arkansas 72205, United States; Recruiting
Covina, California 91723, United States; Recruiting
El Cajon, California 92020, United States; Recruiting
Fullerton, California 92835, United States; Recruiting
Hemet, California 92543, United States; Recruiting
Long Beach, California 90806, United States; Recruiting
Orange, California 92868, United States; Recruiting
San Diego, California 92108, United States; Recruiting
San Leandro, California 94578, United States; Recruiting
Upland, California 91786, United States; Recruiting
Whittier, California 90606, United States; Recruiting
Aurora, Colorado 80045, United States; Recruiting
Colorado Springs, Colorado 80920, United States; Recruiting
Denver, Colorado 80230-7127, United States; Recruiting
Bridgeport, Connecticut 06606, United States; Recruiting
Danbury, Connecticut 06810, United States; Recruiting
Hamden, Connecticut 06518, United States; Recruiting
Trumbull, Connecticut 06611, United States; Recruiting
Lewes, Delaware 19958, United States; Recruiting
Newark, Delaware 19713, United States; Recruiting
Aventura, Florida 33180, United States; Recruiting
Dunedin, Florida 34698, United States; Recruiting
Miami Lakes, Florida 33016, United States; Recruiting
Miami, Florida 33136, United States; Recruiting
Miami, Florida 33135, United States; Recruiting
Naples, Florida 34102, United States; Recruiting
Orlando, Florida 32806, United States; Recruiting
Orlando, Florida 32836, United States; Recruiting
Orlando, Florida 34761, United States; Recruiting
Palm Habor, Florida 34684, United States; Recruiting
Palm Harbor, Florida 34684, United States; Recruiting
Sarasota, Florida 34239, United States; Recruiting
St. Petersburg, Florida 33708, United States; Recruiting
Tamarac, Florida 33321, United States; Recruiting
Tampa, Florida 33614, United States; Recruiting
Tampa, Florida 33613, United States; Recruiting
Duluth, Georgia 30096, United States; Recruiting
Gainesville, Georgia 30501, United States; Recruiting
Lawrenceville, Georgia 30046, United States; Recruiting
Idaho Falls, Idaho 83404, United States; Recruiting
Springfield, Illinois 62703, United States; Recruiting
Indianapolis, Indiana 46202, United States; Recruiting
Indianapolis, Indiana 46227, United States; Recruiting
Lexington, Kentucky 40515, United States; Recruiting
Monroe, Louisiana 71203, United States; Recruiting
Hagerstown, Maryland 21740, United States; Recruiting
Wheaton, Maryland 20902, United States; Recruiting
Boston, Massachusetts 02111, United States; Completed
Fall River, Massachusetts 02720, United States; Recruiting
Mansfield, Massachusetts 02048, United States; Recruiting
Worcester, Massachusetts 01605, United States; Recruiting
Worcester, Massachusetts 01610, United States; Recruiting
Lansing, Michigan 48910, United States; Completed
Lansing, Michigan 48910, United States; Recruiting
Petoskey, Michigan 49770, United States; Recruiting
St. Claire Shores, Michigan 48081, United States; Recruiting
Duluth, Minnesota 55805, United States; Recruiting
Eagan, Minnesota 55121, United States; Recruiting
Flowood, Mississippi 39232, United States; Recruiting
Florissant, Missouri 63031, United States; Recruiting
Kansas CIty, Missouri 64111, United States; Recruiting
Lee's Summit, Missouri 64086, United States; Recruiting
Saint Louis, Missouri 63117, United States; Recruiting
Saint Louis, Missouri 63141, United States; Recruiting
Las Vegas, Nevada 89128, United States; Recruiting
Lebabon, New Hampshire 03756, United States; Recruiting
Nashua, New Hampshire 03060, United States; Recruiting
Manalapan, New Jersey 07726, United States; Recruiting
Toms River, New Jersey 08755, United States; Recruiting
Toms River, New Jersey 08775, United States; Recruiting
Voorhees, New Jersey 08043, United States; Recruiting
Albuquerque, New Mexico 87102, United States; Recruiting
Las Cruces, New Mexico 88011, United States; Recruiting
Brooklyn, New York 11201, United States; Recruiting
Manhasset, New York 11030, United States; Recruiting
New York, New York 10016, United States; Recruiting
Orchard Park, New York 14127, United States; Recruiting
Plainview, New York 11803, United States; Recruiting
Smithtown, New York 11787, United States; Recruiting
Syracuse, New York 13210, United States; Recruiting
Asheville, North Carolina 28803, United States; Recruiting
Charlotte, North Carolina 28210, United States; Recruiting
Durham, North Carolina 27704, United States; Recruiting
Greensboro, North Carolina 27408, United States; Recruiting
Hickory, North Carolina 28602, United States; Recruiting
Leland, North Carolina 28451, United States; Recruiting
Raleigh, North Carolina 27617, United States; Recruiting
Bismarck, North Dakota 58501, United States; Recruiting
Bismark, North Dakota 58507, United States; Recruiting
Akron, Ohio 44333, United States; Recruiting
Cincinnati, Ohio 45219, United States; Recruiting
Cleveland, Ohio 44109, United States; Recruiting
Columbus, Ohio 43203, United States; Recruiting
Columbus, Ohio 43215, United States; Recruiting
Dayton, Ohio 45417, United States; Recruiting
Middleburg Heights, Ohio 44130, United States; Recruiting
Toledo, Ohio 43606, United States; Recruiting
Ardmore, Oklahoma 73401, United States; Recruiting
Oklahoma City, Oklahoma 73103, United States; Recruiting
Oklahoma City, Oklahoma 73112, United States; Recruiting
Tulsa, Oklahoma 74104, United States; Recruiting
Tulsa, Oklahoma 74135, United States; Recruiting
Portland, Oregon 97225, United States; Recruiting
Duncansville, Pennsylvania 16635, United States; Recruiting
Erie, Pennsylvania 16508, United States; Recruiting
Philadelphia, Pennsylvania 19152, United States; Recruiting
Wexford, Pennsylvania 15090, United States; Recruiting
Wyomissing, Pennsylvania 19610, United States; Recruiting
Charleston, South Carolina 29406, United States; Recruiting
Columbia, South Carolina 29204, United States; Recruiting
Greenville, South Carolina 29601, United States; Recruiting
Jackson, Tennessee 38305, United States; Recruiting
Memphis, Tennessee 38119, United States; Recruiting
Amarillo, Texas 79124, United States; Recruiting
Austin, Texas 78731, United States; Recruiting
Austin, Texas 78758, United States; Recruiting
Beaumont, Texas 77701, United States; Recruiting
College Station, Texas 77845, United States; Recruiting
Corpus Christi, Texas 78404, United States; Recruiting
Dallas, Texas 75231-4406, United States; Recruiting
Dallas, Texas 75231, United States; Recruiting
Houston, Texas 77004, United States; Recruiting
Houston, Texas 77007, United States; Completed
Houston, Texas 77074, United States; Recruiting
Houston, Texas 77034, United States; Recruiting
Mesquite, Texas 75150, United States; Recruiting
San Antonio, Texas 78217, United States; Not yet recruiting
San Antonio, Texas 78229, United States; Recruiting
San Antonio, Texas 78232, United States; Recruiting
San Marcos, Texas 78666, United States; Recruiting
Victoria, Texas 77901, United States; Recruiting
Waco, Texas 76708, United States; Recruiting
Olympia, Washington 98502, United States; Recruiting
Spokane, Washington 99204, United States; Recruiting
Wenatchee, Washington 98801, United States; Recruiting
Clarksburg, West Virginia 26301, United States; Terminated
Glendale, Wisconsin 53217, United States; Recruiting
Manitowoc, Wisconsin 54220, United States; Recruiting
Onalaska, Wisconsin 54605, United States; Terminated